中国农业科学院哈尔滨兽医研究所

哈兽研阐明结核分枝杆菌PE_PGRS23蛋白抑制巨噬细胞自噬促进病原菌胞内存活的机制

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04-10 Zhenyang Guo, Haonan Kang, Zixuan Feng, Xueli Zhang, Jiahao Shi, Jinhao Li, Ziyu Song, Lirun Xiang , Bangjun Gong, Hu Xu, Chaoliang Leng, Guohui Zhou, Qian Wang, Yandong Tang, Tongqing An, Xuehui Cai, Zhijun Tian, Jinmei Peng, Hongliang Zhang. Persistent Circulation of Pseudorabies Virus Variants in China: Genomic Features, Pathogenic Characteristics, and Cross-Protective Efficacy of Variant Strain Vaccines .Transbound Emerg Dis. doi：10.1155/tbed/5341313
04-10 Shibo Su #, Mingxia Sun #, Haiwei Wang #, Yan-Dong Tang, Jin Chen, Xinqi Shi, Shuang Cai, Hanrong Zhou, Wei Yang, Ning Zhang, Yongbo Yang, Shujie Wang, Kai Zhao 5, Hongliang Zhang, Zhijun Tian, Xuehui Cai , Yu Lu, Fandan Meng , Tongqing An. Nanobody-based bioPROTAC for viral protein degradation provides an antiviral strategy for porcine arterivirus .J Nanobiotechnology. doi：10.1186/s12951-026-04348-8
04-10 Lingzhai Meng, Yuntong Chen, Mengmeng Yu, Yongzhen Liu, Suyan Wang, Xiaoxiao Xue, Wenrui Fan, Ying Wang, Tao Zhang, Peidong Guo, Ru Guo, Mingxue Hu, Xiaole Qi, Yanping Zhang, Yulu Duan, Hongyu Cui, Yulong Gao. Mutation of lysine 396 of the fusion protein reduces its binding affinity with integrin αVβ1 and leads to attenuation of avian metapneumovirus subtype B .mBio. doi：10.1128/mbio.00424-26
04-10 Qiu Xu, Yao Zhu, Stefan Schwarz, Shuangyu Xie, Jiyun Chai, Longhua Lin, Hongfei Sun, Susu Du, Simeng Liu, Jie Hou, Yongshan Song, Andrea Brenciani, Wanjiang Zhang. Characterization of a ST412-K57 colistin-resistant hypervirulent Klebsiella pneumoniae strain of chicken origin .J Antimicrob Chemother. doi：10.1093/jac/dkag114
04-10 Yulong Zhang, Hangbo Yu, Ziwen Wu, Guodong Wang, Runhang Liu, Dan Ling, Erjing Ke, Suyan Wang, Yuntong Chen, Yongzhen Liu, Hongyu Cui, Yanping Zhang, Yulong Gao , Xiaole Qi. Immune protection in chickens via lipid nanoparticle-encapsulated VP2 DNA vaccine against very virulent infectious bursal disease virus .Poult Sci. doi：10.1016/j.psj.2026.106830
04-10 Hui Wang #, Yingying Cui #, Guanghui Dang, Jiajun Zhang, Yiyi Tang, Tingting Feng, Xinxin Zang, Ningning Song, Siguo Liu. Transcriptional regulator Rv2250c affects isoniazid resistance by down-regulating the expression of efflux pump Rv3728 in Mycobacterium tuberculosis .Arch Microbiol. doi：10.1007/s00203-026-04866-x
04-10 Bei Niu #, Shi-Meng Liu #, Shu-Jian Zhang, Yu-Ting Huang, Jian-Hui Zhang, Sen Hu, Zhi-Gao Bu , Rong-Hong Hua. SPCS2 serves as a critical host factor for JEV replication by regulating viral protein stability and virion assembly .Microbiol Spectr. doi：10.1128/spectrum.03848-25
04-10 He Zhang. Editorial for Special Issue "Animal Viral Infectious Diseases" .Microorganisms. doi：10.3390/microorganisms14030717

研究进展

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