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团队成员

李呈军

发布日期：2022-07-17 10:31 浏览次数：

1、个人简历

李呈军，男，中国农业科学院哈尔滨兽医研究所研究员，博士生导师，动物流感基础与防控研究创新团队助理首席。2014年获得国家自然科学基金“优秀青年科学基金”资助，2016年入选科技部创新人才推进计划“中青年科技创新领军人才”和中国农业科学院“科研英才培育工程”，2017年入选中国农业科学院“农科英才”B类人才。兼任兽医生物技术国家重点实验室副主任、中国微生物学会病毒学专业委员会委员、中国畜牧兽医学会理事和Virology Journal期刊流感栏目副主编。2000年以来，一直专注于流感病毒的基础和防控研究，以第一或通讯作者在Nature Microbiology，PNAS，Protein & Cell，PLoS Pathogens，mBio，Journal of Virology等杂志发表SCI论文20多篇。主持国家自然科学基金优青项目、重大项目课题、面上项目、黑龙江省杰青项目，是国家自然科学基金创新研究群体项目、“十三五”和“十四五”国家重点研发计划项目及黑龙江省兽医病毒学创新研究“头雁”团队学术骨干。

2、联系方式

电话：0451-51051688

电子邮箱：lichengjun@caas.cn

通讯地址：哈尔滨市香坊区哈平路678号

3、教育经历

1996.09–2000.06 河北农业大学 兽医专业 学士

2000.09–2005.06 中国农业科学院研究生院 预防兽医学专业 博士

4、工作经历

2005.07–2005.09 中国农业科学院哈尔滨兽医研究所 助理研究员

2005.10–2010.04 美国威斯康星-麦迪逊大学 博士后

2010.05–2012.10 美国威斯康星-麦迪逊大学 助理科学家

2012.10–至今 中国农业科学院哈尔滨兽医研究所 研究员

2019.09–2022.06 中国农业科学院哈尔滨兽医研究所 科研管理与国际合作处处长

2022.06–至今 中国农业科学院哈尔滨兽医研究所 兽医生物技术国家重点实验室副主任

5、承担主要科研项目（不超过10项 ）

  1. 国家自然科学基金重大项目课题：潜在流行风险动物源性人兽共患病毒致病及跨种传播机制（32192453），2022.01-2026.12，284.8万元，主持。

  2. 岭南现代农业科学与技术广东省实验室科研项目：新发/突发畜禽动物疫病的阻断技术研究（NT2021007），2021.10-2024.09，1500万元，子课题主持。

  3. 国家重点研发计划项目：动物流感病毒的流行规律与传播机制研究（2021YFD1800200），2021.05-2025.12，5500万元，参加。

  4. 黑龙江省杰出青年科学基金：TRIM家族蛋白调控流感病毒复制机制研究（JQ2019C005），2019.07-2022.07，50万元，主持。

  5. 黑龙江省“头雁计划”项目：兽医病毒学创新研究头雁团队，2019.01-2023.12，4000万，学术骨干。

  6. 国家重点研发计划项目：动物流感病毒遗传变异与致病机理研究（2016YFD0500200），2016.07-2021.06，4200万元，参加。

  7. 国家自然科学基金创新研究群体项目：动物流感病毒的进化及其与宿主互作机制（31521005），2016.01-2021.12，1200万元，学术骨干。

  8. 国家自然科学基金优秀青年科学基金：流感病毒感染与变异（31422054），2015.01-2017.12，100万元，主持。

  9. 国家自然科学基金面上项目：流感病毒M2 蛋白与宿主蛋白的相互作用及其分子机制研究（31472215），2015.01-2018.12，79万元，主持。

  10. 中央级公益性科研院所基本科研业务费专项：WNT-β-Catenin信号通路对流感病毒复制的调控机制研究（0302013016），2013.01-2014.12，110万元，主持。

6、代表论文与著作 

  1. Guangwen Wang#, Yuhui Zhao#, Yuan Zhou#, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen*, Chengjun Li*. PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. PLoS Pathog. 2022 Apr 4;18(4):e1010446.

  2. Yuhui Zhao#, Xia Wen#, Qibing Li, Li Jiang, Guangwen Wang, Libin Liang, Xiurong Wang, Hualan Chen*, Chengjun Li*. Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus. J Integr Agric. 2022 Jul; 21(7):2095–2105.

  3. Wenjun Shi, Li Jiang, Miaomiao Ye, Bo Wang, Yu Chang, Zhibo Shan, Xuyuan Wang, Yuzhen Hu, Hualan Chen*, Chengjun Li*. A Single Amino Acid Residue R144 of SNX16 Affects Its Ability to Inhibit the Replication of Influenza A Virus. Viruses. 2022 Apr 15;14(4):825.

  4. Jiaqi Cui, Pengfei Cui, Jianzhong Shi, Weifeng Fan, Xin Xing, Wenli Gu, Yuancheng Zhang, Yaping Zhang, Xianying Zeng, Yongping Jiang, Pucheng Chen, Huanliang Yang, Yan Chen, Jinxiong Liu, Liling Liu, Guobin Tian, Yixin Lu, Hualan Chen, Chengjun Li*, Guohua Deng*. Continued evolution of H6 avian influenza viruses isolated from farms in China between 2014 and 2018. Transbound Emerg Dis. 2021 Jun 30;doi: 10.1111/tbed.14212.

  5. Junping Li#, Libin Liang#, Li Jiang#, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen*, Chengjun Li*. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission. PLoS Pathog. 2021 Feb 11;17(2):e1009336.

  6. Nan Sun#, Li Jiang#, Miaomiao Ye, Yihan Wang, Guangwen Wang, Xiaopeng Wan, Yuhui Zhao, Xia Wen, Libin Liang, Shujie Ma, Liling Liu, Zhigao Bu, Hualan Chen*, Chengjun Li*. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914.

  7. Chengjun Li, Hualan Chen*. H7N9 Influenza Virus in China. Cold Spring Harb Perspect Med. 2021 Aug 2;11(8):a038349.

  8. Guangwen Wang, Li Jiang, Jinliang Wang, Jie Zhang, Fandi Kong, Qibing Li, Ya Yan, Shanyu Huang, Yuhui Zhao, Libin Liang, Junping Li, Nan Sun, Yuzhen Hu, Wenjun Shi, Guohua Deng, Pucheng Chen, Liling Liu, Xianying Zeng, Guobin Tian, Zhigao Bu, Hualan Chen, Chengjun Li*. The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry. J Virol. 2020 Jan 6;94(2):e01707-19.

  9. Libin Liang#, Li Jiang#, Junping Li, Qingqing Zhao, Jinguang Wang, Xijun He, Shanyu Huang, Qian Wang, Yuhui Zhao, Guangwen Wang, Nan Sun, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Jinxiong Liu, Pucheng Chen, Zhigao Bu, Yoshihiro Kawaoka*, Hualan Chen*, Chengjun Li*. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio. 2019 Jun 18;10(3):e01162-19.

  10. Weiyu Luo#, Jie Zhang#, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li*, Li Jiang*, Hualan Chen*. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog. 2018 Jan 19;14(1):e1006851.

  11. Guangwen Wang, Jie Zhang, Fandi Kong, Qibing Li, Jinliang Wang, Shujie Ma, Yuhui Zhao, Libin Liang, Junping Li, Nan Sun, Lizheng Guan, Yuan Zhou, Chenchen Zhou, Shanyu Huang, Zhigao Bu, Li Jiang, Hualan Chen*, Chengjun Li*. Generation and application of replication-competent Venus-expressing H5N1, H7N9, and H9N2 influenza A viruses. Sci Bull. 2018 Feb 15;63(3):176-186.

  12. Pengyang Zhu, Libin Liang, Xinyuan Shao, Weiyu Luo, Shuitao Jiang, Qingqing Zhao, Nan Sun, Yuhui Zhao, Junping Li, Jinguang Wang, Yuan Zhou, Jie Zhang, Guangwen Wang, Li Jiang, Hualan Chen*, Chengjun Li*. Host cellular protein TRAPPC6A△ interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking. J Virol. 2016 Dec 16;91(1):e01757-16.

  13. Chengjun Li#, Masato Hatta#, David F Burke#, Jihui Ping#, Ying Zhang#, Makoto Ozawa, Andrew S Taft, Subash C Das, Anthony P Hanson, Jiasheng Song, Masaki Imai, Peter R Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A Russell, Sarah L James, Eugene Skepner, Eileen A Maher, Gabriele Neumann, Alexander I Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E Wentworth, Jacqueline M Katz, Nancy J Cox, Derek J Smith*, Yoshihiro Kawaoka*. Selection of antigenically advanced variants of seasonal influenza viruses. Nat Microbiol. 2016 May 23;1(6):16058.

  14. Xiurong Wang#, Linlin Gu#, Jianzhong Shi, Haifeng Xu, Ying Zhang, Xianying Zeng, Guohua Deng, Chengjun Li*, Hualan Chen*. Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses. J Integr Agric. 2017 Sep; 16(9):2055–2061.

  15. Libin Liang#, Guohua Deng#, Jianzhong Shi, Shuai Wang, Qianyi Zhang, Huihui Kong, Chunyang Gu, Yuntao Guan, Yasuo Suzuki, Yanbing Li, Yongping Jiang, Guobin Tian, Liling Liu, Chengjun Li*, Hualan Chen*. Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China. J Virol. 2015 Nov 18;90(3):1455-1469.  

  16. Chengjun Li, Hualan Chen*. Enhancement of influenza virus transmission by gene reassortment. Curr Top Microbiol Immunol. 2014;385:185-204.

  17. Chengjun Li, Zhigao Bu, Hualan Chen*. Avian influenza vaccines against H5N1 'bird flu'. Trends Biotechnol. 2014 Mar;32(3):147-156.

  18. Guohua Deng#, Dan Tan#, Jianzhong Shi, Pengfei Cui, Yongping Jiang, Liling Liu, Guobin Tian, Yoshihiro Kawaoka, Chengjun Li*, Hualan Chen*. Complex reassortment of multiple subtypes of avian influenza viruses in domestic ducks at the Dongting Lake Region of China. J Virol. 2013 Sep;87(17):9452-9462.

  19. Jianzhong Shi#, Guohua Deng#, Peihong Liu, Jinping Zhou, Lizheng Guan, Wenhui Li, Xuyong Li, Jing Guo, Guojun Wang, Jun Fan, Jinliang Wang, Yuanyuan Li, Yongping Jiang, Liling Liu, Guobin Tian, Chengjun Li*, Hualan Chen*. Isolation and characterization of H7N9 viruses from live poultry markets—Implication of the source of current H7N9 infection in humans. Chin Sci Bull. 2013 Apr;58:1857-1863.

  20. Chengjun Li#, Armand Bankhead 3rd#, Amie J Eisfeld, Yasuko Hatta, Sophia Jeng, Jean H Chang, Lauri D Aicher, Sean Proll, Amy L Ellis, G Lynn Law, Katrina M Waters, Gabriele Neumann, Michael G Katze*, Shannon McWeeney*, Yoshihiro Kawaoka*. Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol. 2011 Nov;85(21):10955-10967.

  21. Chengjun Li#, Masato Hatta#, Chairul A Nidom, Yukiko Muramoto, Shinji Watanabe, Gabriele Neumann, Yoshihiro Kawaoka*. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4687-4692.

  22. Chengjun Li, Masato Hatta, Shinji Watanabe, Gabriele Neumann, Yoshihiro Kawaoka*. Compatibility among polymerase subunit proteins is a restricting factor in the reassortment between equine H7N7 and human H3N2 viruses. J Virol. 2008 Dec;82(23):11880-11888.

  23. Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu, Hualan Chen*. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem Biophys Res Commun. 2008 Jul 25;372(2):293-297.

  24. Yanbing Li#, Chengjun Li#, Liling Liu, Hongwei Wang, Chuanbin Wang, Guobing Tian, Robert G Webster, Kangzhen Yu, Hualan Chen*. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes. 2006 Aug;33(1):117-122.

  25. Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, Hualan Chen*. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology. 2005 Sep 15;340(1):70-83.

  26. 《禽流感》，中国农业出版社，2015年，副主编。

7、获得奖励 

  1. H5N1亚型禽流感重组禽痘病毒活载体疫苗研究与应用，黑龙江省科学技术进步一等奖，第七名，2008年。

  2. 动物流感病毒引起人流感大流行的潜力及其遗传机制，中国农业科学院杰出科技创新奖，第五名，2015年。

  3. 重组禽流感病毒（H5+H7）灭活疫苗的创制及应用，黑龙江省科学技术进步一等奖，第六名，2021年。

8、专利和标准

  1. 李呈军，陈化兰，姜丽，曾显营，施建忠，梁立滨，田国彬. 流感病毒PB1蛋白抗原表位多肽及其用途. 专利授权号：ZL202011328413.4，中国，2021。



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