1、个人简历
刘丽玲,女,博士,副研究员,硕士生导师。动物流感基础和防控研究团队骨干二级,主要从事动物流感分子诊断和分子流行病学研究。2000年以来,一直致力于动物病毒的研究工作。2003年开始从事流感病毒的研究。主持了黑龙江省自然科学基金面上项目,参加了国家自然科学基金面上项目、中国农业科学院创新团队等项目的研究工作;发表SCI论文30余篇,其中第一作者3篇,分别发表在Journal of Integrative Agriculture(2022年,影响因子4.384), Journal of Virology (2016年,影响因子4.606)和 Emerging infectious diseases(2011年,影响因子6.794)上;获得新兽药证书3项;获得中国农业科学院成果转化优秀团队奖、中国农业科学院杰出科技创新奖、黑龙江省科学技术二等奖、黑龙江省科学技术三等奖、哈尔滨市科学技术一等奖、哈尔滨市科学技术二等奖等多项奖励。
2、联系方式
研究方向:兽医微生物及其分子生物学
电话:0451-51051675
邮箱:liuliling@caas.cn
通讯地址:哈尔滨市香坊区哈平路678号
3、教育经历
1991.09-1996.06 东北农业大学 兽医专业 学士
1997.09-2000.06 东北农业大学 临床兽医学专业 硕士
2004.09-2007.06 东北农业大学 预防兽医学专业 博士
4、工作经历
1996.06-1997.08 黑龙江省生物制品一厂 实习研究员
2000.07-2001.12 中国农业科学院哈尔滨兽医研究所 实习研究员
2002.01-2010.12 中国农业科学院哈尔滨兽医研究所 助理研究员
2011.01-至今 中国农业科学院哈尔滨兽医研究所 副研究员
5、承担项目
中国农业科学院创新团队项目,320万元,参加。
6、代表论文与著作
LIU Li-ling, YANG Huan-liang, GUO Fu-sheng, WANG Xiu-rong, DENG Guo-hua, SHI Jian-zhong,TIAN Guo-bin, ZENG Xian-ying. Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea. Journal of Integrative Agriculture 2022, 21(5): 1534–1538.
Liu L, Zeng X, Chen P, Deng G, Li Y, Shi J, Gu C, Kong H, Suzuki Y, Jiang Y, Tian G, Chen H*. Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China. Journal of Virology.2016, 90(21):9797-9805.
Li Y, Liu L, Y. Zhang, Z. Duan, G. Tian, X. Zeng, J. Shi, L. Zhang, and H. Chen*. New avian influenza virus (H5N1) in wild birds, Qinghai, China. Emerging infectious diseases. 2011,17:265-267(共同第一作者).
Zeng X, Chen P, Liu L, Deng G, Li Y, Shi J, Kong H, Feng H, Bai J, Li X, Shi W, Tian G, Chen H*.Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens. Avian Dis. 2016 (1 Suppl):253-5.
Zeng X, Deng G, Liu L, Li Y, Shi J, Chen P, Feng H, Liu J, Guo X, Mao S, Yang F, Chen Z, Tian G, Chen H*. Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 Against Different Clades of H5N1 Viruses Isolated in China and the Democratic People's Republic of Korea.Avian Dis. 2016 (1 Suppl):238-40.
Fan Z, Ci Y, Liu L, Ma Y, Jia Y, Wang D, Guan Y, Tian G, Ma J, Li Y, Chen H*. Phylogenetic and pathogenic analyses of three H5N1 avian influenza viruses (clade 2.3.2.1) isolated from wild birds in Northeast China.Infect Genet Evol. 2015, 29:138-45.
Fan Z, Ci Y, Ma Y, Liu L, Ma J, Li DY, Chen H*. Phylogenetic and pathogenic analysis of a novel H6N2 avian influenza virus isolated from a green peafowl in a wildlife park.Avian Dis. 2014, 58(4):632-7.
Fan Z, Ci Y, Ma Y, Liu L, Wang D, Ma J, Li Y, Chen H*. Phylogenetic analysis of a novel H6N6 avian influenza virus isolated from a green peafowl in China and its pathogenic potential in mice.Infect Genet Evol. 2014, 28:107-12.
Zhao D, Liang L, Li Y, Liu L, Guan Y, Jiang Y, Chen H*. Proteomics.Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses.2012, 12(12):1970-82.
Zhao D, Liang L, Li Y, Jiang Y, Liu L, Chen H*. Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.PLoS One. 2012, 7(11):e50959.
Wang Z, Yang H, Chen Y, Tao S, Liu L, Kong H, Ma S, Meng F, Suzuki Y, Qiao C, Chen H*. A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs. J Virol. 2017,91(21):e00800-17.
Cui P, Deng G, Shi J, Kong H, Liu L, Guan Y, Suzuki Y, Chen H*. New influenza A(H7N7) viruses detected in live poultry markets in China. Virology 2016, 499:165-169.
Li X, Shi J, Guo J, Deng G, Zhang Q, Wang J, He X, Wang K, Chen J, Li Y, Fan J, Kong H, Gu C, Guan Y, Suzuki Y, Kawaoka Y, Liu L, Jiang Y, Tian G, Li Y, Bu Z, Chen H*. Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 avian influenza viruses. PLoS Pathog 2014.10(11):e1004508.
Zhang Y, Zhang Q, Kong H, Jiang Y, Gao Y, Deng G, Shi J, Tian G, Liu L, Liu J, Guan Y, Bu Z, Chen H*. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet. Science.2013, 340: 1459–1463.
Zhang Q, Shi J, Deng G, Guo J, Zeng X, He X, Kong H, Gu C, Li X, Liu J, Wang G, Chen Y, Liu L, Liang L, Li Y, Fan J, Wang J, Li W, Guan L, Li Q, Yang H, Chen P, Jiang L, Guan Y, Xin X, Jiang Y, Tian G,Wang X, Qiao C, Li C, Bu Z, Chen H*. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science.2013, 341: 410–414.
Feng X, Wang Z, Shi J, Deng G, Kong H, Tao S, Li C, Liu L, Guan Y, Chen H*.Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice. J Virol. 2015, 90(4):1872-9.
Xingtian Kong, Lizheng Guan, Jianzhong Shi, Huihui Kong, Yaping Zhang, Xianying Zeng, Guobin Tian, Liling Liu, Chengjun Li, Yoshihiro Kawaoka, Guohua Deng and Hualan Chen.A single-amino-acid mutation at position 225 in hemagglutinin attenuatesH5N6 influenza virus in mice。Emerging Microbes & Infections,2021, 10:2052-2061.
Xin Yin, Guohua Deng, Xianying Zeng, Pengfei Cui, Yujie Hou, Yanjing Liu,Jingzhen Fang, Shuxin Pan, Dongxue Wang, Xiaohan Chen, Yaping Zhang,Xiurong Wang, Guobin Tian, Yanbing Li, Yan Chen, Liling Liu, Yasuo Suzuki,Yuntao Guan, Chengjun Li, Jianzhong Shi, Hualan Chen.Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLOS Pathogens, 2021, 17(4):e1009561.
Lizheng Guan , Jianzhong Shi , Xingtian Kong , Shujie Ma , Yaping Zhang , Xin Yin , Xijun He , Liling Liu , Yasuo Suzuki , Chengjun Li , Guohua Deng , Hualan Chen. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets. Emerg Microbes Infect . 2019, 8(1):1280-1290.
Shi J, Deng G, Kong H, Gu C, Ma S, Yin X, Zeng X, Cui P, Chen Y, Yang H, Wan X, Wang X, Liu L, Chen P, Jiang Y, Liu J, Guan Y, Suzuki Y, Li M, Qu Z, Guan L, Zang J, Gu W, Han S, Song Y, Hu Y, Wang Z, Gu L, Yang W, Liang L, Bao H, Tian G, Li Y, Qiao C, Jiang L, Li C, Bu Z, Chen H.H7N9 virulent mutants detected in chickens in China pose an increased threat to humans.Cell Res. 2017, 27(12):1409-1421.
7、获得奖励
动物流感基础与防控研究创新团队荣获中国农业科学院成果转化优秀团队奖,2020年。
动物流感病毒引起人流感大流行的潜力及其遗传机制,中国农业科学院杰出科技创新奖,陈化兰、施建忠、邓国华、李雁冰、李呈军、曾显营、刘丽玲、姜永萍、何希君、田国彬、关云涛、柳金雄、陈普成、陈艳、杨焕良,2015年。
我国H5N1亚型高致病性禽流感病毒抗原变异株的鉴定及防控研究,黑龙江省科学技术三等奖,陈化兰、李雁冰、田国彬、施建忠、曾显营、姜永萍、刘丽玲、邓国华、王秀荣,2011年。
我国H5N1亚型高致病性禽流感病毒抗原变异株的鉴定及防控研究,哈尔滨市科学技术二等奖,陈化兰、李雁冰、田国彬、施建忠、曾显营、姜永萍、邓国华、王秀荣、刘丽玲,2010年。
禽流感病毒RT-PCR检测技术的研究与应用,黑龙江省科学技术二等奖,王秀荣,于康震,陈化兰,田国彬、乔传玲、刘丽玲、李雁冰、包红梅、邓国华,2006年。
禽流感病毒RT-PCR检测技术的研究与应用,哈尔滨市科技进步一等奖,王秀荣,于康震,陈化兰,田国彬、乔传玲、李雁冰、邓国华、刘丽玲、包红梅,2005年。
重组禽流感病毒H5亚型二价灭活疫苗(细胞源,Re-6株+ Re-4株),三类新兽药证书,新兽药证字20号,2015年。
重组禽流感病毒(H5亚型)二价灭活疫苗(细胞源,Re-6株+ Re-4株),三类新兽药证书,新兽药证字27号,2016年。
重组禽流感病毒(H5+H7)二价灭活疫苗(H5N1 Re-8株+H7N9 H7-Re1株),一类新兽药证书,新兽药证字37号,2019年。