1、个人简历

杨勇博，男，博士，副研究员。主要研究方向为猪蓝耳病、伪狂犬病等猪免疫抑制病病原体侵染与致病机制研究、新型疫苗递送系统的研发。主持中国博士后自然科学基金面上项目1项，黑龙江省自然科学面上项目1项。发表SCI期刊论文20余篇论文；其中以第一作者在Nano Letters、ACS Applied Materials & Interfaces、Theranostics和RSC Advances上发表论文4篇。

2、联系方式

（1）研究方向：猪蓝耳病、伪狂犬病等猪免疫抑制病病原体侵染与致病机制研究、新型疫苗递送系统的研发

（2）电话：0451-51051762

（3）邮箱：yangyongbo@caas.cn

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号，150069

3、教育经历

2001.09-2007.06  黑龙江大学  制药工程（生物制药方向） 学士

2007.09-2010.06  黑龙江大学  微生物学  硕士

2012.03-2017.04  哈尔滨工业大学  生物医学工程  博士

4、工作经历

2010.12-2012.03  中国农科院哈尔滨兽医研究所  科研助理

2017.12-2020.12  中国农科院哈尔滨兽医研究所  助理研究员

2021.01-至今  中国农科院哈尔滨兽医研究所  副研究员

5、主持项目

1. 中国博士后科学基金面上项目一等资助, 2018M630236, 利用新型单颗粒示踪方法对伪狂犬病病毒侵染机制的研究, 8万元；

2. 黑龙江省自然科学基金面上项目, C2018069, 基于量子点的新型病毒示踪方法在伪狂犬病病毒侵染机制研究中的应用, 6万元；

6、代表论文

1. Yang Yong-Bo, Tang Yan-Dong, Hu Yue, Yu Fang, Xiong Jun-Yao, Sun Ming-Xia, Lyu Chuang, Peng Jin-Mei, Tian Zhi-Jun, Cai Xue-Hui*, An Tong-Qing*. Single Virus Tracking with Quantum Dots Packaged into Enveloped Viruses Using CRISPR, Nano Letters, 2020, 20(2): 1417-1427.

2. Yang Yongbo, Lin Li, Jing, Lijia, Yue Xiuli*, Dai Zhifei*. CuInS2/ZnS Quantum Dots Conjugating Gd(III) Chelates for Near-Infrared Fluorescence and Magnetic Resonance Bimodal Imaging, ACS Applied Materials & Interfaces, 2017, 9(28): 23450-23457.

3. Yang Yongbo, Jing Lijia, Li Xiaoda, Lin Li, Yue Xiuli*, Dai Zhifei*. Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics. Theranostics, 2017, 7(2): 466-481.

4. Yang Yongbo, Wang Jinrui, Li Xiaoda, Lin Li, Yue Xiuli*. A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction. RSC Advances, 2014, 5(11): 8404-8414.

5. Junyao Xiong #, Xingyang Cui #, Kuan Zhao #, Qian Wang, Xinyi Huang, Dongyan Li, Fang Yu, Yongbo Yang, Di Liu, Zhijun Tian, Xuehui Cai, Tongqing An*. A Novel Motif in the 3′-UTR of PRRSV-2 Is Critical for Viral Multiplication and Contributes to Enhanced Replication Ability of Highly Pathogenic or L1 PRRSV. Viruses, 2022, 14(2): 166.

6. Xiao-Xiao Tian, Tao Wang, Xing-Yang Cui, Xin-Yi Huang, Yue Sun, Da-Song Xia, Yong-Bo Yang, Xue-Hui Cai, Tong-Qing An*. Rapid visual detection of porcine reproductive and respiratory syndrome virus via recombinase polymerase amplification combined with a lateral flow dipstick. Archives of Virology, 2022, 167: 493–499.

7. Lei Qin #, Fandan Meng #, Haijuan He, Yong-Bo Yang, Gang Wang, Yan-Dong Tang, Mingxia Sun, Wenlong Zhang, Xuehui Cai*, Shujie Wang*. A Virulent Trueperella pyogenes Isolate, Which Causes Severe Bronchoconstriction in Porcine Precision-Cut Lung Slices. Frontiers in Veterinary Science, 2021, 8: 824349.

8. Yang Yue-Lin #, Liu Jianbo #, Wang Tong-Yun #, Chen Meng #, Wang Gang, Yang Yong-Bo, Geng Xin, Sun Ming-Xia, Meng Fandan*, Tang Yan-Dong*, Feng Li*. Aminopeptidase N is an Entry Co-Factor Triggering Porcine Deltacoronavirus Entry via an Endocytotic Pathway. Journal of Virology, 2021,95(21): e0094421.

9. Lyu Chuang, Li Wei-Dong, Wang Shu-Wen, Peng Jin-Mei, Yang Yong-Bo, Tian Zhi-Jun, Cai Xue-Hui*. Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-Terminal 181 L- 185 L and Plays a Negative Regulation Role during Viral Lytic Infection. International Journal of Molecular Sciences, 2020, 21(9): 3148

10. Yu Fang #, Yan Yi #, Shi Mang, Liu Hai-Zhou, Zhang Hong-Liang, Yang Yong-Bo, Huang Xin-Yi, Gauger C Phillip, Zhang Jianqiang, Zhang Yan-He, Tong Guang-Zhi, Tian Zhi-Jun, Chen Jian-Jun, Cai Xue-Hui*, Liu Di*, Li Ganwu*, An Tong-Qing*. Phylogenetics, Genomic Recombination, and NSP2 Polymorphic Patterns of Porcine Reproductive and Respiratory Syndrome Virus in China and the United States in 2014-2018. Journal of Virology, 2020, 94(6): e01813-19.

11. Wang Shujie, Lyu Chuang, Duan Guixin, Meng Fandan, Yang Yongbo, Yu Ying, He Xijun, Wang Zhenzhong, Gottschalk Marcelo, Li Ganwu, Cai Xuehui*, Wang Gang*. Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation through Induction of Thymic Atrophy. Infection and Immunity, 2020, 88(4): e00950-19.

12. Zhao Kuan #, Gao Jia-Cong #, Xiong Jun-Yao #, Guo Jin-Chao, Yang Yong-Bo, Jiang Cheng-Gang, Tang Yan-Dong, Tian Zhi-Jun, Cai Xue-Hui, Tong Guang-Zhi, An Tong-Qing*. Two Residues in NSP9 Contribute to the Enhanced Replication and Pathogenicity of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus. Journal of Virology, 2018, 92(7): e02209-17.

7、获得奖励

中国农业科学院，优秀博士后。2020年