孟凡丹，女，博士，研究员，硕士/博士研究生导师。中国农业科学院“青年英才计划”引进工程院级入选者。主要研究方向为PRRSV感染与致病机制及防控技术研究。主持国家自然科学基金青年项目1项、黑龙江省自然科学基金优秀青年项目1项。以第一或通讯作者在Journal of Nanobiotechnology、Emerging microbes & infections、Journal of Virology等SCI期刊上发表论文27篇。指导在读硕士研究生2名、在读博士研究生3名。

1、联系方式

研究方向：PRRSV感染与致病机制及防控技术研究

电话：0451-51051768

邮箱：mengfandan@caas.cn

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号，150069

2、教育经历 

2016.04-2019.04  德国汉诺威兽医大学，兽医学，DVM

2011.10-2015.10  德国汉诺威兽医大学，病毒学，PhD

2008.09-2011.06  东北农业大学，预防兽医学，硕士

2003.09-2008.06  东北农业大学，动物医学，学士

3、工作经历 

2023.01-至今 中国农业科学院哈尔滨兽医研究所，研究员

2018.07-2022.12 中国农业科学院哈尔滨兽医研究所

2015.10-2017.09 德国汉诺威兽医大学，博士后

4、主持或参与科研项目

1). 国家自然科学基金青年科学基金项目：塞内卡谷病毒经猪呼吸道上皮细胞感染的入侵机制研究（32002249, 2021.01-2023.12），24万元

2). 黑龙江省自然科学基金优秀青年项目：高致病性PRRSV引起猪肺组织损伤分子机制的研究（YQ2019C030，2019.07-2022.07），10万元

3). 国家兽用生物制品工程技术研究中心开放课题：靶向PRRSV关键复制酶的生物药物创制及递送技术研究（GTKF(23)008，2023.06-2025.12）,18万元

5、代表论文与著作

1). Su S, Sun M, Wang H, Tang YD, Chen J, Shi X, Cai S, Zhou H, Yang W, Zhang N, Yang Y, Wang S, Zhao K, Zhang H, Tian Z, Cai X, Lu Y, Meng F*, An T*. Nanobody-based bioPROTAC for viral protein degradation provides an antiviral strategy for porcine arterivirus. J Nanobiotech. 2026, doi:10.1186/s12951-026-04348-8.

2). Meng L, Tian XX, Xiang XY, Qi XY, Zhou HR, Xiao PY, An TQ, Meng F*, Wang HW*. Epitope mapping of Senecavirus A 3A protein using monoclonal antibodies. Transbound Emerg Dis. 2025, 2025:3398924.

3). Tian X, Wei Z, Khan M, Zhou Z, Zhang J, Huang X, Yang Y, Wang S, Wang H, Cai X, Meng F*, An T*. Refining lineage classification and updated RFLP patterns of PRRSV-2 revealed viral spatiotemporal distribution characteristics in China in 1991–2023. Transbound Emerg Dis. 2025, 2025:9977088.

4). Rao CH, Huang R, Bai YZ, Yu C, Chen M, Peng JM, Xu SJ, Sun MX, Wang SJ, Yang YB, An TQ, Tian ZJ, Lyu C, Cai XH, Zheng C, Meng F*, Tang YD*. MARCH8 inhibits pseudorabies virus replication by trapping the viral cell-to-cell fusion complex in the trans-Golgi network. Int J Biol Macromol. 2024, 274:133463.

5). Wang TY#, Meng F#, Sang GJ, Zhang HL, Tian ZJ, Zheng H*, Cai XH*, Tang YD*. A novel viral vaccine platform based on engineered transfer RNA. Emerg Microbes Infect. 2023, 12:2157339.

6). Yang YL, Liu J, Wang TY, Chen M, Wang G, Yang YB, Geng X, Sun MX, Meng F*, Tang YD*, Feng L*. Aminopeptidase N is an entry co-factor triggering porcine deltacoronavirus entry via an endocytotic pathway. J Virol. 2021, 95(6):e0094421.

7). Yang YL#, Meng F#, Qin P, Herrler G, Huang YW*, Tang YD*. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerg Microbes Infect. 2020, 9:457-468.

8). Meng F, Tong J, Désirée V, Peng J, Cai X, Maren W, Georg H, Naihuei W, Peter VW. Viral co-infection replaces effects of suilysin on adherence and invasion of Streptococcus suis into respiratory epithelial cells grown under air-liquid interface conditions. Infect Immun. 2019, 87(8):e00350-19.

9). Tong J, Fu Y, Wu NH, Manfred R, Meng F*, Peter VW*, Georg H*. Sialic acid-dependent interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and invasion mechanism. Cell Microbiol. 2018, 20(4).

10). Yang W, Punyadarsaniya D, Lambertz RL, Lee DC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F*, Herrler G*. Mutations during the adaptation of H9N2 avian influenza virus to the respiratory epithelium of pigs enhance the sialic acid binding activity and the virulence in mice. J Virol. 2017, 91(5):e02125-16.

11). Yang W, Lambertz RLO, Punyadarsaniya D, Leist SR, Stech J, Schughart K, Herrler G*, Wu NH*, Meng F*. Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells. Vet Microbiol. 2017, 211:129-134.

12). Wu NH, Yang W, Beineke A, Dijkman R, Matrosovich M, Baumgärtner W, Thiel V, Valentin-Weigand P, Meng F*, Herrler G*. The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells. Sci Rep. 2016, 6:39668.

13). Meng F, Wu NH, Seitz M, Herrler G, Valentin-Weigand P. Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions. Sci Rep. 2016, 6:26748.

14). Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. Dynamic viral-bacterial interactions in a porcine precision-cut lung slice co-infection model: swine influenza virus paves the way for Streptococcus suis infection in a two-step process. Infect Immun. 2015, 83:2806-2815.

15). Meng F, Punyadarsaniya D, Uhlenbruck S, Hennig-Pauka I, Schwegmann-Wessels C, Ren X, Dürrwald R, Herrler G. Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses. Vet Res. 2013, 44:110.