1、个人简历

孟凡丹，女，博士，研究员，硕士/博士研究生导师。中国农业科学院“青年英才计划”引进工程院级入选者。主要研究方向：呼吸道病原体感染呼吸系统分子机制研究以及呼吸道病原体混合感染协同致病机制相关研究。主持黑龙江省自然科学基金优秀青年项目1项，国家自然科学基金青年项目1项。以第一或通讯作者在Journal of Virology、Cellular Microbiology和Infection and Immunity等国际著名SCI期刊上发表论文11篇。指导在读硕士研究生1名、在读博士研究生3名。

2、联系方式

（1）研究方向：病原组织嗜性、混合感染协同致病机制研究

（2）电话：0451-51051768

（3）邮箱：mengfandan@caas.cn

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号，150069

3、教育经历 

2016.04 - 2019.04  德国汉诺威兽医大学，病毒学，DVM

2011.10 - 2015.10  德国汉诺威兽医大学，病毒学，PhD

2008.09 - 2011.06  东北农业大学，预防兽医学，硕士

2003.09 - 2008.06  东北农业大学，动物医学，学士

4、工作经历

2022.02 - 至今 中国农业科学院哈尔滨兽医研究所，研究员

2018.07 - 2022.02 中国农科院哈尔滨兽医研究所  

2015.10 - 2017.09  德国汉诺威兽医大学，博士后

5、主持或参与科研项目

1. 黑龙江省自然科学基金优秀青年项目：高致病性PRRSV引起猪肺组织损伤分子机制的研究（YQ2019C030，2019.07-2022.07），10万元

2. 国家自然科学基金青年科学基金项目：塞内卡谷病毒经猪呼吸道上皮细胞感染的入侵机制研究（32002249, 2021.01-2023.12），24万元

6、代表论文与著作

1. Yang, Y.L*., Meng, F*., Qin, P., Herrler, G., Huang, Y.W., Tang, Y.D., 2020. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerging microbes & infections 9, 457-468. 

2. Meng F, Tong J, Vötsch D, Peng J-Y, Cai X, Willenborg M, Herrler G, Wu N-H, Valentin-Weigand P, 2019. Viral co-infection replaces effects of suilysin on adherence and invasion of Streptococcus suis into respiratory epithelial cells grown under air-liquid interface conditions. Infection and immunity.doi:10.1128/IAI.00350-19.

3. Tong J, Fu Y, Wu N-H, Rohde M, Meng F*, Valentin‐Weigand P*, Herrler G*, 2018. Sialic acid-dependent interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and invasion mechanism. Cellular Microbiology. DOI:10.1111/cmi.12818.

4. Yang W, Punyadarsaniya D, Lambertz RL, Lee DC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F*, Herrler G*, 2017. Mutations during the adaptation of H9N2 avian influenza virus to the respiratory epithelium of pigs enhance the sialic acid binding activity and the virulence in mice. J Virol. JVI.02125-16. doi: 10.1128/JVI.02125-16.

5. Yang, Wei; L.O. Lambertzb, Ruth; Punyadarsaniyac, Darsaniya; R. Leist, Sarah; Stech, Jürgen; Schughart, Klaus; Herrler, Georg; Wu, Nai-Huei; Meng, F, 2017. Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells, Veterinary Microbiology, 10.16, 211: 129-134.

6. Wu NH, Yang W, Beineke A, Dijkman R, Matrosovich M, Baumgärtner W, Thiel V, Valentin-Weigand P, Meng F*, Herrler G*, 2016. The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells. Scientific reports. 6:39668. doi: 10.1038/srep39668.

7. Meng F, Wu NH, Seitz M, Herrler G, Valentin-Weigand P, 2016. Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions. Scientific reports. 6, 26748.

8. Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. 2015. Dynamic viral-bacterial interactions in a porcine precision-cut lung slice co-infection model: swine influenza virus paves the way for Streptococcus suis infection in a two-step process. Infection and immunity. 83, 2806-2815.

9. Meng F, Suo S, Zarlenga DS, Cong Y, Ma X, Zhao Q, Ren X. 2014. A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry. Virology. 456-457:20-7. doi: 10.1016/j.virol.2014.01.010.

10. Meng F, Punyadarsaniya D, Uhlenbruck S, Hennig-Pauka I, Schwegmann-Wessels C, Ren X, Dürrwald R, Herrler G. 2013. Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses. Vet Res. 13;44:110. doi: 10.1186/1297-9716-44-110.

11. Meng F, Ren Y, Suo S, Sun X, Li X, Li P, Yang W, Li G, Li L, Schwegmann-Wessels C, Herrler G, Ren X. 2013. Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus. PLoS One. 8(3):e57468. doi: 10.1371/journal.pone.0057468. Epub 2013 Mar 19.