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团队成员

汤艳东

1、个人简历

汤艳东,男,博士,副研究员,硕士研究生导师。主要研究内容:1.重要动物病毒分子生物学;2.前沿技术在病毒中的应用;3.新型疫苗的研发。发表SCI论文90余篇,其中以第一或通讯作者在《Journal of Virology》《Journal of Biological Chemistry》《Emerging Microbes & Infections》《FASEB J》《Vet Microbiology》《Virology》等国际期刊上发表论文30余篇,其中发表在《Journal of Biological Chemistry》杂志的不同物种受体对新冠病毒SARS-COV-2的易感性研究,被联合国粮农组织评估性政策文件《Exposure of humans or animals toSARS-CoV-2 from wild, livestock, companion and aquatic animals》基本全文引用。担任《Frontiers in Microbiology》《Archives of Virology》《Frontiers in Immunology》编委。担任《Viruses》专栏客座主编。获2016年中国农业科学院优秀博士后、2019年中国农业科学院-杰出科技创新奖,及2021年《Frontiers in Microbiology》杂志杰出编委奖“Outstanding Review Editor Award”。

2、联系方式

(1)研究方向:重要动物病毒分子生物学及新型疫苗研发

(2)电话:0451-51051765/18249466512

(3)邮箱:tangyandong@caas.cn

(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号,150069

3、教育经历 

2003.09-2007.06  黑龙江八一农垦大学 生物科学 学士

2008.09-2011.06  中国农业科学院 生物化学与分子生物学 硕士

2011.09-2014.06  南方医科大学 医学免疫学 博士

4、工作经历

2014.07-2019.12  中国农科院哈尔滨兽医研究所  助理研究员

2020.01-至今  中国农科院哈尔滨兽医研究所  副研究员

5、在研项目

1. 黑龙江省自然科学基金优秀青年基金:伪狂犬病毒拮抗cGas-STING通路的分子机制(YQ2019C028,2019.10-2022.10),10万元(主持)。

2. “十三五” 国家重点研发计划项目:伪狂犬病毒重要糖蛋白抗原表位图谱分析(2016YFD050010402,2016.07-2020.12),140万元(参与)。

6、近5年代表论文与著作

1. Wang TY, Meng FD, Sang GJ, Zhang HL, Tian ZJ, Zheng H, Cai XH, Tang YD. 2023. A novel viral vaccine platform based on engineered transfer RNA. Emerg Microbes Infect 12:2157339.(通讯作者)

2. Wang TY, Sang GJ, Wang Q, Leng CL, Tian ZJ, Peng JM, Wang SJ, Sun MX, Meng FD, Zheng H, Cai XH, Tang YD. 2022. Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology. Viruses 14. (通讯作者)

3. Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD. 2022. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner. J Virol 96:e0131822.(通讯作者)

4. Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S, Yin X, Cai XH, Tang YD. 2022. SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. J Biol Chem 298:102511. (通讯作者)

5. Zhang YY, Sun MX, Lian Y, Wang TY, Jia MY, Leng C, Chen M, Bai YZ, Meng F, Cai XH, Tang YD. 2022. CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus. Front Microbiol 13:835040. (通讯作者)

6. Yang YL, Liu J, Wang TY, Chen M, Wang G, Yang YB, Geng X, Sun MX, Meng F, Tang YD, Feng L. 2021. Aminopeptidase N Is an Entry Co-factor Triggering Porcine Deltacoronavirus Entry via an Endocytotic Pathway. J Virol 95:e0094421. (通讯作者)

7. Zhang HL, Li YM, Sun J, Zhang YY, Wang TY, Sun MX, Wang MH, Yang YL, Hu XL, Tang YD, Zhao J, Cai X. 2021. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. J Biol Chem 296:100435. (通讯作者)

8. Wang TY, Sun MX, Zhang HL, Wang G, Zhan G, Tian ZJ, Cai XH, Su C, Tang YD. 2021. Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus. Front Microbiol 12:693799. (通讯作者)

9. Yang YL, Meng F, Qin P, Herrler G, Huang YW, Tang YD. 2020. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerg Microbes Infect 9:457-468. (通讯作者)

10. Wang TY, Yang YL, Feng C, Sun MX, Peng JM, Tian ZJ, Tang YD, Cai XH. 2020. Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-kappaB Activation by Degrading P65. Viruses 12. (通讯作者)

11. Wang Y, Liu TX, Wang TY, Tang YD, Wei P. 2020. Isobavachalcone inhibits Pseudorabies virus by impairing virus-induced cell-to-cell fusion. Virol J 17:39. (通讯作者)

12. Wang TY, Fang QQ, Cong F, Liu YG, Wang HM, Zhang HL, Tian ZJ, Tang YD, Cai XH. 2019. The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis. Emerg Microbes Infect 8:1501-1510. (通讯作者)

13. Tang YD, Guo JC, Wang TY, Zhao K, Liu JT, Gao JC, Tian ZJ, An TQ, Cai XH. 2018. CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing. FASEB J 32:4293-4301. (通讯作者)

14. Zhang HL, Zhang WL, Xiang LR, Leng CL, Tian ZJ, Tang YD, Cai XH. 2018. Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China. Vet Microbiol 222:105-108. (通讯作者)

15. Wang TY, Liu YG, Li L, Wang G, Wang HM, Zhang HL, Zhao SF, Gao JC, An TQ, Tian ZJ, Tang YD, Cai XH. 2018. Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection. Oncotarget 9:12174-12185.


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