
王淑杰,博士,副研究员,硕士生导师。主要研究方向为猪免疫抑制性疾病(S. suis、PRRSV、PRV)的临床免疫学研究及动物诊断试剂研发。主持国家自然科学基金面上项目、黑龙江省自然科学基金项目、黑龙江省留学回国人员择优资助项目、中国农业科学院基础科研业务专项;参与国家973 项目、“十一五”/“十二五”科技重大专项等;Clinical Microbiology、BMC Microbiology等杂志审稿人;发表科技论文80余篇,其中以第一作者及通讯作者在Infection and Immunity,International Journal of Biological Macromolecules,Frontiers in Microbiology,Microbiology Spectrum,Microorganisms等杂志发表SCI论文25篇,累计影响因子103.1。
1、联系方式
邮箱:wangshujie@caas.cn
通讯地址:黑龙江省哈尔滨市香坊区哈平路678号,150069
2、教育经历
2010.09-2013.06 东北农业大学,动物医学院,博士
2001.09-2004.06 东北农业大学,动物医学院,硕士
1997.09-2001.06 东北农业大学,动物医学院,学士
3、工作经历
2021.01-至今 中国农业科学院哈尔滨兽医研究所, 猪蓝耳病与伪狂犬病研究创新团队, 副研究员
2017.03-2020.12 中国农业科学院哈尔滨兽医研究所, 助理研究员
2016.03-2017.03 加拿大蒙特利尔大学,访问学者/博士后
2008.01-2016.03 中国农科院哈尔滨兽医研究所, 助理研究员
2004.07-2007.12 中国农科院哈尔滨兽医研究所,实习研究员
4、承担主要科研项目
1). 国家自然科学基金面上项目,NLRP1途径介导猪链球菌感染引起猪胸腺T细胞凋亡的分子机制研究(32273018,2023-2026), 71.5万元,主持
2). 黑龙江省自然基金联合引导项目,NLRP3炎症小体介导猪链球菌引起猪脾脏B细胞凋亡的机制(LH2023C048,2023-2026),10万元,主持
3). 中国农业科学院基础科研业务专项,高致病性PRRSV引起仔猪免疫抑制的分子机制研究(1610302022006,2022-2025),27.61万元,主持
4). 省留学回国人员择优资助项目,猪链球菌通过p53信号转导通路诱导胸腺细胞凋亡的分子机制研究(2018QD0031,2018-2021),5万元,主持
5). “十二五”国家科技重大专项,猪链球菌和大肠杆菌流行规律研究(2012ZX10004214-0005-013,2012-2015), 45万元,参与
6). “十一五”国家科技重大专项,猪链球菌抗原基因的发掘和功能验证(2009ZX10004214,2010-2012), 60万元,参与
7). 卫生部专项,猪链球菌病原谱流行规律研究(2009CB504401,2010-2012),60万元,参与
8). 973项目,链球菌病原生态学与流行病学调查(2006CB504401,2007-2011),40万元,参与
5、代表论文与著作
1). Wang SJ#*, Chen TF#, Yang YB, Wang HF, Sun MX, Gao KX, Wei ZY, Bai YZ, Tang YD, Cai XH*, An TQ*. Development of blocking ELISA for detection anti-PRRSV antibodies and serological investigation of PRRSV in China. Int J Biol Macromol. 2025, 296(3):139670.
2). He HJ#, Li H#, Yan L, Wang G, Liu YG, An TQ, Tu YB, Wang SJ*, Cai XH*. Hepatitis E virus detection in swine livers and feces in Heilongjiang, Northeastern China. Microorganisms. 2025, 13(8):1899.
3). Pan SY#, He HJ#, An TQ*, Wang SJ*. Streptococcus suis: a review of its effects on immune organs. Microorganisms. 2025, 13(7):1613.
4). Yue FJ, Zhao Y, Lv Y, Li S, Wang W, Li Y, Wang SJ*, Wang CS*. Anti-tumor effects of sheep umbilical cord mesenchymal stem cells on melanoma cells. Int J Mol Sci. 2025, 26(1):426.
5). Bai YZ#, Wang SJ#, Sun Y, Liu YG, Zhang HL, Wang Q, Huang R, Rao CH, Xu SJ, Tian ZJ, An TQ, Cai XH*, Tang YD*. The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2. J Virol. 2025, 99(1):e01821-24.
6). Shen XG#, Yang YB#, Gao YF#, Wang SJ#, Wang HW, Sun MX, Meng FD, Tang YD, Tu YB, Kong QK, An TQ, Cai XH. Lipid A-modified Escherichia coli can produce porcine parvovirus virus-like particles with high immunogenicity and minimal endotoxin activity. Microb Cell Fact. 2024, 23(8):222.
7). Li SQ#, Chen TF#, Gao KX, Yang YB, Qi BJ, Wang CS, An TQ, Cai XH*, Wang SJ*. Streptococcus suis induces macrophage M1 polarization and pyroptosis. Microorganisms. 2024, 12(9):1879.
8). Yang JW#, Dong YT#, Hu LXY, Wang WH, Li YJ, Wang SJ*, Wang CS*. Immortalization of mesenchymal stem cell lines from sheep umbilical cord tissue. Biology. 2024, 13(7):551.
9). Qin L#, Meng FD#, He HJ, Li SQ, Zhang HL, Sun YL, Zhang WL, An TQ, Cai XH*, Wang SJ*. Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo. Infect Immun. 2023, 91(12):e00273-23.
10). He HJ#, Qi BJ#, Yang YB#, Cui XW, Chen TF, Cai XH*, An TQ*, Wang SJ*. Immunogenicity characterization of the recombinant gI protein fragment from pseudorabies virus and an evaluation of its diagnostic use in pigs. Vet Sci. 2023, 10(8):506.
11). Wang SJ#, Xu MJ#, Yang KB, Zhang Y, Li SQ, Tang YD, Wang JL, Leng CL, An TQ, Cai XH*. Streptococcus suis contributes to inguinal lymph node lesions in piglets after highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) infection. Front Microbiol. 2023, 14(4):1159590.
12). Li SQ, Wang CS, Tang YD, Qin L, Chen TF, Wang SH, Bai YZ, Cai XH, Wang SJ*. Interaction between porcine alveolar macrophage-Tang cells and Streptococcus suis strains of different virulence: phagocytosis and apoptosis. Microorganisms. 2023, 11(1):160.
13). Wang SJ#*, Wang G#, Tang YD#, Li SQ, Qin L, Wang MH, Yang YB, Gottschalk M, Cai XH*. Streptococcus suis serotype 2 infection induces splenomegaly with splenocyte apoptosis. Microbiol Spectr. 2022, 10(6):e0321022.
14). Zhang YY#, Liang R#, Wang SJ#, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S*, Yin X*, Cai XH, Tang YD*. SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. J Biol Chem. 2022, 298(11):102511.
15). Qin L#, Meng FD#, He HJ, Yang YB, Wang G, Tang YD, Sun MX, Zhang WL, Cai XH*, Wang SJ*. A virulent Trueperella pyogenes isolate, which causes severe bronchoconstriction in porcine precision-cut lung slices. Front Vet Sci. 2022, 8(1):824349.
16). Wang SJ*, Zhang DF, Jiang CG, He HJ, Cui CC, Duan WT, Hu SP, Wang J, Cai XH*. Strain characterization of Streptococcus suis serotypes 28 and 31, which harbor the resistance genes optrA and ant(6)-Ia. Pathogens. 2021, 10(2):213.
17). Wang SJ*, Wang CS, Ren X, Xue WJ, He HJ, Zhu YZ, Wang HF, Wang G, Cai XH*. Identification of two novel linear neutralizing epitopes within the hexon protein of canine adenovirus using monoclonal antibodies. Vaccines. 2021, 9(2):135.
18). Wang SJ, Lyu C, Duan GX, Meng FD, Yang YB, Yu Y, He XJ, Wang ZG, Gottschalk M, Li GW, Cai XH*, Wang G*. Streptococcus suis serotype 2 infection causes host immunomodulation through induction of thymic atrophy. Infect Immun. 2020, 88(4):e00950-19.
19). Wang SJ, Wen YJ, An TQ, Duan GX, Sun MX, Ge JY, Li X, Yang KB*, Cai XH*. Development of an immunochromatographic strip for rapid detection of canine adenovirus. Front Microbiol. 2019, 10(12):2882.
20). Wang SJ#, Dai EH#, Jiang XY, Zeng LJ, Cheng QX, Jing Y, Hu LF, Yin Z, Gao B, Wang JL, Duan GX, Cai XH*, Zhou DS*. Characterization of the plasmid of incompatibility groups IncFIIpKF727591 and IncpKPHS1 from Enterobacteriaceae species. Infect Drug Resist. 2019, 12(9):2789-2797.
21). Wang SJ, Gao MM, An TQ, Liu YG, Jin JM, Zhou DS*, Cai XH*. Genetic diversity and virulence of novel sequence types of Streptococcus suis from healthy and diseased pigs in China. Front Microbiol. 2015, 6(3):173.
22). Pian YY#, Gan SZ#, Wang SJ#, Guo J, Wang PP, Zheng YL, Cai XH*, Jiang YQ*. Fhb, a novel factor H-binding surface protein, contributes to the antiphagocytic ability and virulence of Streptococcus suis. Infect Immun. 2012, 80(7):2402.
6、专利
1). 王淑杰,李艳华,蔡雪辉,安同庆。大豆皂苷在制备预防和/或治疗猪繁殖与呼吸道综合征的药物中的应用,ZL202511349507.2
2). 蔡雪辉,孙明霞,涂亚斌,王淑杰。识别PCV2病毒样颗粒的单克隆抗体及其在定性及定量检测PCV2病毒样颗粒中的应用,ZL201811261025.1
3). 蔡雪辉,王淑杰,金家民,刘永刚。猪链球SBP_bac_5基因缺失株及其构建方法和应用,ZL201510058245.4
4). 王淑杰,蔡雪辉。一种兽医检验用样品采集装置,ZL201920619966.1
5). 蔡雪辉,王淑杰。一种兽医实验室消毒装置,ZL201920607561.6
7、获得奖励与荣誉
1). 动物分子病原学科技创新团队;哈尔滨市科技创新团队奖;2016年
2). 猪繁殖与呼吸综合征防控创新团队;中华农业科技奖(一等奖);2015年
3). 猪链球菌耐药性研究及安全高效新兽药的研制;黑龙江省科技进步奖(二等奖);2013年
4). 猪繁殖与呼吸综合征活疫苗(CH-1R 株)的研制与应用;黑龙江省科技进步奖(一等奖);2009年
5). 猪繁殖与呼吸综合征防制技术的研究及应用;中华农业科技奖(二等奖);2009年
6). 重大外来新发人兽共患烈性传染病防控技术储备研究;中国农业科学院科技进步奖(二等奖);2007年