1、个人简历

郭龙军，男，博士，副研究员，猪消化道传染病团队，主要从事猪腹泻病毒等基础免疫学研究。近年来以第一作者发表SCI论文15篇，其中Journal of Virology论文4篇；主持国家自然科学基金项目及黑龙江省自然科学基金各一项；主持中国农业科学院优秀青年引导项目一项，参与“十四五”国家重点研发计划、国家自然科学基金、黑龙江省自然科学基金等多项项目。

2、联系方式

（1）研究方向：兽医微生物及其分子生物学

（2）电话：0451-51051715

（3）邮箱：guolongjun@caas.cn

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

2003.09-2007.06  青岛农业大学 动物医学专业 学士

2007.09-2012.06  中国农业科学院哈尔滨兽医研究所 预防兽医学专业 博士

4、工作经历

2012.07-2012.12  中国农科院哈尔滨兽医研究所 研究实习员

2013.01-2016.12  中国农科院哈尔滨兽医研究所 助理研究员

2017.01-至今 中国农科院哈尔滨兽医研究所 副研究员

5、承担项目

1. 国家自然科学基金青年科学基金项目：细胞自噬对猪传染性胃肠炎病毒感染的抑制作用研究（31500128，2016.01-2018.12），25万元；主持

2. 中国农业科学院优秀青年引导项目：猪流行性腹泻病毒（PEDV）抑制Ⅰ型干扰素产生的分子机制研究（Y2017JC05，2017.01-2019.12），60万元；主持

3. 黑龙江省自然科学基金项目：猪源金属蛋白酶ADAM17对PEDV感染的抑制作用研究（QC2014C038，2016.07-2017.06），5万元；主持

4.“十四五”国家重点研发计划课题：宿主对畜禽冠状病毒的免疫应答与免疫保护机制（2021YFD1801105，2021.12-2024.11），1100万元；骨干参与

6、代表论文与著作

1. Mingwei Li, Yang Wu, Jianfei Chen, Hongyan Shi, Zhaoyanag Ji, Xin Zhang, Da Shi, Jianbo Liu, Jin Tian, Xiaobo Wang, Zhaorong Shi, Hongling Zhang, Hao Zhang, Longjun Guo*, Li Feng*. Innate Immune Evasion of Porcine Epidemic Diarrhea Virus through Degradation of the FBXW7 Protein via the Ubiquitin-Proteasome Pathway. Journal of Virology. 2022, 88(18): 9;96(5):e0088921. (Co-corresponding author)

2. Longjun Guo, Junwei Niu, Haidong Yu, Weihong Gu, Ren Li, Xiaolei Luo, Mingming Huang, Zhijun Tian, Li Feng, Yue Wang*. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. Journal of Virology. 2014, 88(18): 10448-10458.

3. Longjun Guo, Xiaolei Luo, Ren Li, Yunfei Xu, Jian Zhang, Jinying Ge, Zhigao Bu, Li Feng, Yue Wang*. Porcine epidemic diarrhea virus infection inhibits interferon signaling by targeted degradation of STAT1. Journal of Virology. 2016, 90(18): 8281-8292.

4. Xiaolei Luo#, Longjun Guo#, Jian Zhang, Yunfei Xu, Weihong Gu, Li Feng, Yue Wang*. Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor. Journal of Virology. 2017, 91(10): 00202-00217. (Co-first author)

5. Yang Wu, Zhaorong Shi, Jianfei Chen, Hongling Zhang, Mingwei Li, Ying Zhao, Hongyan Shi, Da Shi, Longjun Guo*, Li Feng*. Porcine Deltacoronavirus E Protein Induces Interleukin-8 Production Via Nf-Κb and Ap-1 Activation. Veterinary Microbiology. 2022, 274:109553. (Co-corresponding author)

6. Yang Wu, Hongling Zhang, Jianfei Chen, Zhaorong Shi, Mingwei Li, Ying Zhao, Hongyan Shi, Da Shi, Longjun Guo*, Li Feng*. Stromal Antigen 2 Deficiency Induces Interferon Responses and Restricts Porcine Deltacoronavirus Infection. Viruses. 2022, 14(8):1783. (Co-corresponding author)

7. Mingwei Li, Longjun Guo*, Li Feng*. Interplay between Swine Enteric Coronaviruses and Host Innate Immune. Frontiers in Veterinary Science. 2022, 9:1083605. (Co-corresponding author)

8. Yang Wu, Hongling Zhang, Zhaorong Shi, Jianfei Chen, Mingwei Li, Hongyan Shi, Da Shi, Longjun Longjun Guo*, Li Feng*. Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3. Viruses. 2020, 12(6):599. (Co-corresponding author)

9. Longjun Guo, Haidong Yu, Weihong Gu, Xiaolei Luo, Ren Li, Jian Zhang, Yunfei Xu, Lijun Yang, Nan Shen, Li Feng, Yue Wang*. Autophagy negatively regulates transmissible gastroenteritis virus replication. Scientific Reports. 2016, 6:23864.

10. Jian Zhang#, Longjun Guo#, Lijun Yang, Jiayu Xu, Lu Zhang, Li Feng, Hongyan Chen, Yue Wang. Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. Virology. 2018,517:24-29. (Co-first author)

11. Weihong Gu#, Longjun Guo#, Ren Li, Junwei Niu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding. Journal of General Virology. 2016, 97(3): 632-638. (Co-first author)

12. Longjun Guo, Yujie Fu, Liping Huang, Yiping Wang, Yanwu Wei, Hongli Wu, Changming Liu*. A commercial PCV2a-based vaccine is effective in protection from experimental challenge of PCV2 mutant with two amino acids elongation in capsid protein. Vaccine. 2015, 33(31): 3752-3757.

13. Weihong Gu, Longjun Guo, Haidong Yu, Junwei Niu, Mingming Huang, Xiaolei Luo, Ren Li, Zhijun Tian, Li Feng, Yue Wang*. Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection. Journal of General Virology. 2015, 96: 1712-1722.

14. Ren Li, Longjun Guo, Weihong Gu, Xiaolei Luo, Jian Zhang, Yunfei Xu, Zhijun Tian, Li Feng, Yue Wang*. Production of porcine TNFalpha by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Immunologic Research. 2016, 64(3): 711-720.

15. Jian Zhang, Longjun Guo, Yunfei Xu, Lijun Yang, Hongyan Shi, Li Feng*, Yue Wang*. Characterization of porcine epidemic diarrhea virus infectivity in human embryonic kidney cells. Archives of Virology. 2017, 162(8): 2415-2419.

7、获得奖励

1. 猪圆环病毒病防控关键技术创新与应用，中国农业科学院科学技术成果一等奖，刘长明，危艳武，陆月华，张超范，黄立平，郭龙军，2013年。

2. 猪圆环病毒2型灭活疫苗产业化开发与推广应用，全国农牧渔业丰收奖二等奖，刘长明，危艳武，陆月华，张超范，黄立平，郭龙军，曲乃昌，刘全胜，成体鸽，陈连和，王云龙，郑新平，闫恒普，耿鸿霜，朱庸康，马平，杨瑞华，顾叶明，李文革，2013年。

3. 猪圆环病毒疫苗及配套诊断技术的研究与产业化，中华农业科技奖三等奖，刘长明，危艳武，陆月华，张超范，黄立平，郭龙军，2013年。