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团队成员

张 鑫

1、个人简历

张鑫,男,博士学位,副研究员,硕士研究生导师,猪消化道传染病创新团队,研究领域为兽医微生物及其分子生物学,主要从事TGEV、PEDV与PoRV等猪病毒性疫病的诊断和病原学、流行病学、免疫学的研究,以及猪腹泻相关病毒蛋白与宿主蛋白的相互作用研究。承担科研项目4项,发表SCI文章10余篇,获得科研奖励4项,培养硕士研究生3名。

2、联系方式

(1)研究方向:兽医微生物及其分子生物学

(2)电话:15145105603/0451-51051720

(3)邮箱:zhangxin01@caas.cn

(4)通讯地址:哈尔滨市香坊区哈平路678号

3、教育经历

1999.09-2003.06 吉林农业大学大学,动物医学专业,学士

2003.09-2006.06 吉林农业大学大学,预防兽医学专业,硕士

2006.09-2009.06 浙江大学,预防兽医学专业,博士

4、工作经历

2009.09-2005.12 中国农科院哈尔滨兽医研究所 ,助理研究员

2006.01-至今  中国农科院哈尔滨兽医研究所,副研究员

5、承担项目

1.“十三五” 国家重点研发计划项目:畜禽重要疫病的微生物组及新发病毒的病原生态学研究(2017YFD0500104,2017.07-2020.12), 50.6万元;

2. 国家自然科学基金:NSP5蛋白与宿主细胞beta tubulin相互作用对PoRV致病性的影响(31502092,2016.01-2018.12),21.6万元(参加);

3. 国家科技支撑(攻关)计划:高致病性蓝耳病等重要家畜疫病新型疫苗研究与开发(2015BAD12B02-6,2015.01-2019.12),100万元(参加);

4. 国家自然科学基金:猪瘟病毒衣壳蛋白核转运机制研究(31101823,2012.01-2015.12),21万元;

6、代表论文与著作

1. Ji Zhaoyang, Dong Hui, Jiao Ruixue, Zhu Xiaoyuan, Shi Hongyan, Chen Jianfei , Shi Da, Liu Jianbo, Jing Zhaoyang, Zhang Jialin, Wang Xiaobo, Ye Dandan, Zhang Jiyu, Zhang Xin#, Feng Li#. The TGEV Membrane Protein Interacts with HSC70 To Direct Virus Internalization through Clathrin-Mediated Endocytosis. Journal of Virology. 2023 Apr 27; 97(4): e0012823. doi: 10.1128/jvi.00128-23. (#co-first author)

2. Ji Zhaoyang, Shi Da, Shi Hongyan, Wang Xiaobo, Chen Jianfei, Liu Jianbo, Ye Dandan, Jing Zhaoyang, Liu Qiuge, Fan Qianjin, Li Mingwei, Cong Guangyi, Zhang Jiyu, Han Yuru, Zhang Xin#, Feng Li#. A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein. Veterinary Microbiology, 2021 Feb; 253: 108955. doi: 10.1016/j.vetmic.2020.108955. (#co-first author)

3. Jing Zhaoyang, Shi Hongyan, Chen Jianfei, Shi Da, Liu Jianbo, Guo Longjun, Tian Jin, Wu Yang, Dong Hui, Ji Zhaoyang, Zhang Jiyu, Zhang Liaoyuan, Zhang Xin#, Feng Li#. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. Journal of Virology, 2021, 95(21): e0124621. (#co-first author);

4. Ji Zhaoyang, Shi Da, Shi Hongyan, Wang Xiaobo, Chen Jianfei, Liu Jianbo, Ye Dandan, Jing Zhaoyang, Liu Qiuge, Fan Qianjin, Li Mingwei, Cong Guangyi, Zhang Jiyu, Han Yuru, Zhang Xin#, Feng Li#. A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein. Veterinary Microbiology. 2021, 253:108955. (#co-first author);

5. Jing Zhaoyang#, Zhang Xin#, Shi Hongyan, Chen Jianfei, Shi Da, Dong Hui, Feng Li#. A G3P[13] Porcine Group A Rotavirus Emerging in China Is a Reassortant and a Natural Recombinant in the VP4 Gene. Transboundary and Emerging Diseases. 2018 Apr;65(2):e317-e328 (#co-first author);

6. Ye Dandan, Ji Zhaoyang, Shi Hongyan, Chen Jianfei, Shi Da, Cao Liyan, Liu Jianbo, Li Mingwei, Dong Hui, Jing Zhaoyang, Wang Xiaobo, Liu Qiuge, Fan Qianjin, Cong Guangyi, Zhang Jiyu, Han Yuru, Zhou Jiyong, Gu Jinyan#, Zhang Xin#, Feng Li#. Molecular characterization of an emerging reassortant mammalian orthoreovirus in China. Archive of Virology. 2020 Oct; 165 (10) :2367-2372 (#co-first author);

7. Zhang Xin, Zhu Yunnuan, Zhu Xiangdong, Shi Hongyan, Chen Jianfei, Shi Da, Yuan Jing,  Cao Liyan, Liu Jianbo, Dong Hui, Jing Zhaoyang, Zhang Jialin, Wang Xiaobo, Feng Li#. Identification of a natural recombinant transmissible gastroenteritis virus between Purdue and Miller clusters in China , Emerging Microbes & Infections, 2017, 6(8): 0-e74;

8. Zhang Xin, Zhu Yunnuan, Zhu Xiangdong, Chen Jianfei, Shi Hongyan, Shi Da, Dong Hui,  Feng Li#. ORF3a deletion in field strains of porcine-transmissible gastroenteritis virus in China: A hint of association with porcine respiratory coronavirus , Transboundary and Emerging Diseases, 20 17.jun, 64(3): 698-702;

9. Zhang Xin, Zhao Xin, Dong Hui, Zhu Yunnuan, Shi Hongyan, Chen Jianfei, Shi Da, Feng Li#. Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein , PLos One, 2016.jun, 11(9): 0-0163920;

10. Dong Hui#, Zhang Xin#, Shi Hongyan, Chen Jianfei, Shi Da, Zhu Yunnuan, Feng Li#. Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane Protein , Viruses-Basel, 2016, 8(12): 0-327 (#co-first author);

7、获得奖励

1. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒三联活疫苗创制与应用,国家技术发明类二等奖,中华人民共和国国务院,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,2018年

2. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗创制与应用,黑龙江省科学技术奖(技术发明类)一等奖,黑龙江省人民政府,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,王洪峰,孙东波,石达,2017年

3. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗,神农中华农业科技奖三等奖,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,王洪峰,孙东波,石达,2017年

4. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗的研制,杰出科技创新奖,中国农业科学院,冯力,时洪艳,陈建飞,佟有恩,张鑫,王牟平,王洪峰,孙东波,石达,2016年


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