1、个人简历
石达,男,农学博士,助理研究员,猪消化道传染病创新团队,从事猪冠状病毒基础与应用研究。近年来以第一作者发表SCI文章12篇;主持国家自然科学基金青年基金项目1项,黑龙江省自然科学基金面上项目1项,中国博士后科学基金面上项目(一等资助)1项,以及广西兽医生物技术重点实验室开放基金。获中国农业科学院技术成果奖(排名第九)1项,黑龙江省科学技术发明一等奖(排名第九)1项。
2、联系方式
研究方向:兽医微生物及其分子生物学
电话:0451-51051721
邮箱:shida@163.com
所在单位:中国农业科学院哈尔滨兽医研究所
通讯地址:哈尔滨市香坊区哈平路678号
3、教育经历
2005.09-2009.06 河北北方学院 动物医学专业 学士
2009.09-2012.06 中国农业科学院研究生院 预防兽医学专业 硕士
1991.09-1996.06 中国农业科学院研究生院 预防兽医学专业 博士
4、工作经历
2015.07-2017.12 中国农科院哈尔滨兽医研究所 助理研究员
2018.01-至今 中国农科院哈尔滨兽医研究所 副研究员
5、承担项目
1. 国家自然科学基金青年科学基金项目:微管正端示踪蛋白EB3对PEDV复制的调控作用及其分子机制(31602072,2017.01-2019.12),20万元。
2. 黑龙江省科学基金面上项目:猪流行性腹泻病毒NSP1蛋白抑制宿主基因表达的分子机制(C2017079,2017.10-2020.10),6万元。
3. 中国博士后科学基金面上项目(一等资助):分子伴侣蛋白HSP47对PEDV复制的调控作用及其分子机制(2017M610136,2017.01-2018.12),8万元。
6、代表论文与著作
1. Shi D, Zhou L, Shi H, Zhang J, Zhang J, Zhang L, Liu D, Feng T, Zeng M, Chen J, Zhang X, Xue M, Jing Z, Liu J, Ji Z, He H, Guo L, Wu Y, Ma J, Feng L. Autophagy is induced by swine acute diarrhea syndrome coronavirus through the cellular IRE1-JNK-Beclin 1 signaling pathway after an interaction of viral membrane-associated papain-like protease and GRP78. PLoS Pathogens. 2023 Mar 8;19(3):e1011201. doi: 10.1371/journal.ppat.1011201.
2. Zhang, J., Zhang, L., Shi, H., Feng, S., Feng, T., Chen, J., Zhang, X., Han, Y., Liu, J., Wang, Y., Ji, Z., Jing, Z., Liu, D., Shi, D*., Feng, L*., 2022. Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. Virology 565, 96-105. (共同通讯)
3. Qin, Y., Feng, T., Shi, H., Zhang, J., Zhang, L., Feng, S., Chen, J., He, Y., Zhang, X., Chen, Z., Liu, J., Liu, D., Shi, D*., Feng, L*., 2022. Identification and epitope mapping of swine acute diarrhea syndrome coronavirus accessory protein NS7a via monoclonal antibodies. Virus research 313, 198742. (共同通讯)
4. Su, M#., Shi, D#., Xing, X., Qi, S., Yang, D., Zhang, J., Han, Y., Zhu, Q., Sun, H., Wang, X., Wu, H., Wang, M., Wei, S., Li, C., Guo, D., Feng, L., Sun, D., 2021. Coronavirus PEDV nucleocapsid protein interacts with p53 to induce cell cycle arrest in S-phase and promotes viral replication. Journal of virology, JVI0018721.(共同第一作者)
5. Ji, Z#., Shi, D#., Shi, H., Wang, X., Chen, J., Liu, J., Ye, D., Jing, Z., Liu, Q., Fan, Q., Li, M., Cong, G., Zhang, J., Han, Y., Zhang, X., Feng, L*., 2021. A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein. Veterinary microbiology 253, 108955.(共同第一作者)
6. Wei, S#., Shi, D#., Wu, H., Sun, H., Chen, J., Feng, L., Su, M., Sun, D., 2021. Identification of a novel B cell epitope on the nucleocapsid protein of porcine deltacoronavirus. Virus research 302, 198497. (共同第一作者)
7. Zhang, J., Han, Y., Shi, H., Chen, J., Zhang, X., Wang, X., Zhou, L., Liu, J., Ji, Z., Jing, Z., Ma, J., Shi, D*., Feng, L*., 2020. Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent. Emerging Microbes & Infections 9, 439-456. (共同通讯)
8. Han, Y., Zhang, J., Shi, H., Zhou, L., Chen, J., Zhang, X., Liu, J., Wang, X., Ji, Z., Jing, Z., Cong, G., Ma, J., Shi, D*., Li, F*., 2019. Epitope mapping and cellular localization of swine acute diarrhea syndrome coronavirus nucleocapsid protein using a novel monoclonal antibody. Virus research 273, 197752. (共同通讯)
9. Shi, D., Wang, X., Shi, H., Zhang, J., Han, Y., Chen, J., Zhang, X., Liu, J., Ji, Z., Jing, Z., Feng, L*., 2019. Significant Interference with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strain Replication in Small-Intestine Epithelial Cells Using an shRNA Expression Vector. Vaccines 7.
10. Shi, D., Shi, H., Sun, D., Chen, J., Zhang, X., Wang, X., Zhang, J., Ji, Z., Liu, J., Cao, L., Zhu, X., Yuan, J., Dong, H., Chang, T., Liu, Y., Feng, L*., 2017. Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV Growth. Scientific reports 7, 39700.
11. Shi, D., Lv, M., Chen, J., Shi, H., Zhang, S., Zhang, X., Feng, L*., 2014. Molecular characterizations of subcellular localization signals in the nucleocapsid protein of porcine epidemic diarrhea virus. Viruses 6, 1253-1273.
12. Shi, D., Zhang, S., Chen, J., Shi, H., Zhang, X., Feng, L*., 2013. Molecular characterization of a porcine kobuvirus variant strain in China. Archives of virology 158, 2379-2383.
7、获得奖励
1. 2021-2022年度“优秀共产党员”荣誉称号。
2. 中国农业科学院2017年度优秀博士后称号。
3.“猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗”的研制,中国农业科学院科学技术成果奖(杰出科技创新奖),冯力,时洪艳,陈建飞,佟有恩,张鑫,王洪峰,王牟平,孙东波,石达,2016年。
4. 猪传染性胃肠炎、猪流行性腹泻、猪轮状病毒(G5型)三联活疫苗创制与应用,黑龙江省科学技术奖(技术发明类一等奖),冯力,时洪艳,陈建飞,佟有恩,张鑫,王洪峰,王牟平,孙东波,石达,2017年。