1、个人简历

贾洪林，男，博士，研究员，研究生导师，宠物疫病创新团队首席，第九届中国动物学会寄生虫专业委员会委员，第七届、八届中国畜牧兽医学会兽医寄生虫学分会理事。目前承担国家重点研发专项，国家自然科学基金以及省自然科学基金等多个项目。主要研究方向为猫宠物疫病以及弓形虫等宠物源人兽共患病的病原生物学研究以及防控制剂研发。在PLoS Pathogens、Autophagy、Nature Structural & Molecular Biology和mBio等国际著名期刊发表SCI文章50多篇，被引用700多次，担任多个国际期刊审稿人。

2、联系方式

研究方向：宠物传染病研究

电话：045151051782

邮箱：jiahonglin@caas.cn

通讯地址：哈尔滨市哈平路678号

3、教育经历

1997.09-2001.06  延边大学 兽医专业 学士

2001.09-2004.06  延边大学 预防兽医专业 硕士

2006.04-2009.03  日本带广畜产大学 畜产卫生专业 博士

4、工作经历

2004.07-2005.01  延边大学 助教

2005.02-2006.03  日本带广畜产大学国立原虫病研究中心 研究职员

2009.04-2011.09  日本北海道大学人兽共患病研究中心 博士后

2011.10-2020.12  中国农业科学院哈尔滨兽医研究所 副研究员

2021.01-至今  中国农业科学院哈尔滨兽医研究所 研究员

5、承担项目

(1) 黑龙江省杰出青年基金：弓形虫顶质体跨膜转运分子机制，2022-2025

(2) 黑龙江省重点研发专项：伴侣动物疫病防控制剂创制，2022-2025

(3) “十四五” 国家重点研发计划项目：动物重要寄生虫的生长发育与寄生机制，2022-2025

(4) 国家自然科学基金面上项目：弓形虫SNARE蛋白在分泌性细胞器生物发生过程中的作用机制研究，2018-2022

(5) “十三五” 国家重点研发计划项目：畜禽重要胞内寄生原虫的寄生与免疫机制研究，2017-2022

(6) “十三五” 国家重点研发计划项目：畜禽重要人兽共患寄生虫病源头防控与阻断技术研究，2017-2022

(7) 国家自然科学基金青年基金项目：弓形虫氨基肽酶的功能解析及其作为药物靶点的可行性研究，2012-2015

(8) 黑龙江省自然科学基金面上项目：弓形虫甲硫氨酸氨基肽酶药物靶点的鉴定，2015-2017

6、代表论文与著作

1. Fu J, Zhao L, Chen H, Cao S, Jia H*. An unconventional SNARE complex mediates exocytosis at the plasma membrane and vesicular fusion at the apical annuli in Toxoplasma gondii. PLoS Pathogens. 2023, 19(3):e1011288

2. Cao H, Gu H, Kang H* and Jia H*. Development of a rapid reverse genetics system for feline coronavirus based on TAR cloning in yeast. Front. Microbiol. 2023, 14:1141101.

3. Fu J, Zhao L, Pang Y, Chen H, Yamamoto H, Chen Y, Li Z, Mizushima N,Jia H*. Apicoplast biogenesis mediated by ATG8 requires the ATG12-ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondii. Autophagy. 2023, 19(4):1258-1276.

4. The Dissection of SNAREs Reveals Key Factors for Vesicular Trafficking to the Endosome-like Compartment and Apicoplast via the Secretory System in Toxoplasma gondii. Cao S., Yang J., Fu J., Chen H., Jia H*. mBio. 2021,12(4):e0138021. 通讯作者

5. Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Pang, Y., Yamamoto, H., Sakamoto, H., Oku, M., Mutungi, J. K., Sahani, M. H., Kurikawa, Y., Kita, K., Noda, N. N. & Sakai, Y., Jia, H.*, Mizushima, N*.  Nature structural & molecular biology, 2019, 26: 289-296, 共同通讯作者

6. TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii. Zheng, J., Su, W., Cao, S., Zhang, Z., Du, C., Jia, H.* International Journal for Parasitology, 2020,50 :487-499, 通讯作者

7. Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway, Li, J., Guo, H., Galon, E.M., Gao, Y., Lee, S., Liu, M., Li, Y., Ji, S., Jia, H*., Xuan，X*., Antimicrob Agents Chemother, 2020, 64(3): e01889-19. 共同通讯作者

8. GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. Zhang, Z., Gu, H., Li, Q., Zheng, J., Cao, S., Weng, C., Jia, H.* Infection and Immunity, 2020, 88: e00054-20, 通讯作者

9. The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii. Cao, S., Chen, H., Liang, X., Fu, J., Wang, S., Zheng, J., Zhang, Z., Pang, Y., Wang, J. & Shen, B., Jia, H.*.  Molecular microbiology, 2019, 113: 208-221, 通讯作者

10. Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development. Zheng, J., Chen, Y., Li, Z., Cao, S., Zhang, Z. & Jia, H.* FASEB J, 2018, 32: 906-919, 通讯作者

11. Knockout of leucine aminopeptidase in Toxoplasma gondii using CRISPR/Cas9. Zheng, J., Jia, H.*, & Zheng, Y. International Journal for Parasitology, 2015, 45:141-148, 通讯作者

12. Characterization of aspartyl aminopeptidase from Toxoplasma gondii. Zheng, J., Cheng, Z., Jia, H.* & Zheng, Y. Sci Rep, 2016, 6: 34448, 通讯作者

13. Toxoplasma gondii Clp family protein: TgClpB1 plays a crucial role in thermotolerance. Cao, S., Nali Du, Chen, H., Pang, Yu., Zhang, Z., Zheng, J. Jia, H.* Oncotarget. 2017, 8:86117-86129.

14. Wang, M., Cao, S., Du, N., Fu, J., Li, Z., Jia, H.＊, Mingxin Song*. The moving junction protein RON4, although not critical, facilitates host cell invasion and stabilizes MJ members. Parasitology. 2017, 144(11): 1490-1497

15. Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii. Yang, M., Zheng, J., Jia, H.,*, Song, M.* Parasitology. 2016, 143(11):1443-9.

16. Meng, X., ,  Zheng, J.,  He, X., Jia, H. *, Zhang, Y.* First characterization in China of Encephalitozoon cuniculi in the blue fox (Alopex lagopus). J Eukaryot Microbiol. 2014, 61(6):580-5.

17. Evaluation of spore wall protein 1 as an alternative antigen for the diagnosis of Encephalitozoon cuniculi infection of farmed foxes using an enzyme-linked immunosorbent assay. Meng, X., Zheng, J., Gao, Y., Zhang, Y*. & Jia, H* . Veterinary Parasitology, 2014, 203: 331-334, 通讯作者

18. Jia, H., Nishikawa, Y., Luo, Y., Yamagishi, J., Sugimoto, C., Xuan, X., Characterization of a leucine aminopeptidase from Toxoplasma gondii. Mol Biochem Parasitol 170, 1-6.

19. Jia, H., Zhou, J., Ikadai, H., Matsuu, A., Suzuki, H., Igarashi, I., Fujisaki, K., Xuan, X., 2006. Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its use in serodiagnosis. Am J Trop Med Hyg 75, 843-850.

20. Jia, H., Liao, M., Lee, E., Nishikawa, Y., Inokuma, H., Ikadai, H., Matsuu, A., Igarashi, I., Xuan, X., 2007. Development of an immunochromatographic test with recombinant BgSA1 for the diagnosis of Babesia gibsoni infection in dogs. Parasitol Res 100, 1381-1384.

21. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2008. Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen. Exp Parasitol 118, 146-149.

22. Jia, H., Aboge, G.O., Terkawi, M.A., Goo, Y.K., Nishikawa, Y., Kuriki, K., Lee, K.K., Jang, H.K., Kim, S., Fujisaki, K., Xuan, X., 2009. Genetic diversity of two selected antigen loci in Babesia gibsoni Asian genotype obtained from Japan and Jeju island of South Korea. Vet Parasitol 162, 142-146.

23. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Luo, Y., Li, Y., Yamagishi, J., Nishikawa, Y., Igarashi, I., Sugimoto, C., Fujisaki, K., Xuan, X., 2009. Characterization of a leucine aminopeptidase of Babesia gibsoni. Parasitology 136, 945-952.

24. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Ma, L., Zhou, J., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2009. Identification of secreted antigen 3 from Babesia gibsoni. Clin Vaccine Immunol 16, 944-948.