1、个人简历

贾洪林，男，博士，研究员，博士研究生导师，宠物疫病创新团队首席。目前承担国家重点研发专项，国家自然科学基金以及省自然科学基金等多个项目。主要研究方向为猫宠物疫病等宠物源人兽共患病的病原生物学研究以及防控制剂研发。在PLoS Pathogens、Autophagy、Nature Structural & Molecular Biology、mBio和JV等国际著名期刊发表SCI文章50多篇，被引用700多次，担任多个国际期刊审稿人。

2、联系方式

研究方向：宠物传染病研究

电话：045151051782

邮箱：jiahonglin@caas.cn

通讯地址：哈尔滨市哈平路678号

3、工作经历

2004.07-2005.01  延边大学 助教

2005.02-2006.03  日本带广畜产大学国立原虫病研究中心 研究职员

2009.04-2011.09  日本北海道大学人兽共患病研究中心 博士后

2011.10-2020.12  中国农业科学院哈尔滨兽医研究所 副研究员

2021.01-至今  中国农业科学院哈尔滨兽医研究所 研究员

4、承担项目

(1) “十四五” 国家重点研发计划项目，2023-2026

(2) 黑龙江省杰出青年基金项目，2022-2025

(3) 黑龙江省重点研发计划项目，2022-2025

(4) “十四五” 国家重点研发计划项目子课题，2022-2025

(5) 国家自然科学基金面上项目，2018-2022

(6) “十三五” 国家重点研发计划项目子课题，2017-2022

(7) “十三五” 国家重点研发计划项目子课题，2017-2022

(8) 国家自然科学基金青年基金项目，2012-2015

(9) 黑龙江省自然科学基金面上项目，2015-2017

5、代表论文与著作

1. Heng W, Zang D, Li R, Jiang Q, Liu J, Jia H, Kang H. A novel replication-deficient FCV vaccine provides strong immune protection in cats. J Virol. 2025 Jul 8:e0009325. 共同通讯

2. Cao H, Gu H, Kang H, Jia H. Development of a rapid reverse genetics system for feline coronavirus based on TAR cloning in yeast. Front Microbiol. 2023, 14:1141101. 通讯作者

3. Fu J, Zhao L, Chen H, Cao S, Jia H*. An unconventional SNARE complex mediates exocytosis at the plasma membrane and vesicular fusion at the apical annuli in Toxoplasma gondii. PLoS Pathogens. 2023, 19(3):e1011288. 通讯作者

4. Cao H, Gu H, Kang H* and Jia H*. Development of a rapid reverse genetics system for feline coronavirus based on TAR cloning in yeast. Front. Microbiol. 2023, 14:1141101.

5. Fu J, Zhao L, Pang Y, Chen H, Yamamoto H, Chen Y, Li Z, Mizushima N, Jia H*. Apicoplast biogenesis mediated by ATG8 requires the ATG12-ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondii. Autophagy. 2023, 19(4):1258-1276. 通讯作者

6. The Dissection of SNAREs Reveals Key Factors for Vesicular Trafficking to the Endosome-like Compartment and Apicoplast via the Secretory System in Toxoplasma gondii. Cao S., Yang J., Fu J., Chen H., Jia H*. mBio. 2021,12(4):e0138021. 通讯作者

7. Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Pang, Y., Yamamoto, H., Sakamoto, H., Oku, M., Mutungi, J. K., Sahani, M. H., Kurikawa, Y., Kita, K., Noda, N. N. & Sakai, Y., Jia, H.*, Mizushima, N*.  Nature structural & molecular biology, 2019, 26: 289-296. 共同通讯作者

8. TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii. Zheng, J., Su, W., Cao, S., Zhang, Z., Du, C., Jia, H.* International Journal for Parasitology, 2020,50 :487-499. 通讯作者

9. Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway, Li, J., Guo, H., Galon, E.M., Gao, Y., Lee, S., Liu, M., Li, Y., Ji, S., Jia, H*., Xuan，X*., Antimicrob Agents Chemother, 2020, 64(3): e01889-19. 共同通讯作者

10. GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon. Zhang, Z., Gu, H., Li, Q., Zheng, J., Cao, S., Weng, C., Jia, H.* Infection and Immunity, 2020, 88: e00054-20. 通讯作者

11. The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii. Cao, S., Chen, H., Liang, X., Fu, J., Wang, S., Zheng, J., Zhang, Z., Pang, Y., Wang, J. & Shen, B., Jia, H.*.  Molecular microbiology, 2019, 113: 208-221. 通讯作者

12. Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development. Zheng, J., Chen, Y., Li, Z., Cao, S., Zhang, Z. & Jia, H.* FASEB J, 2018, 32: 906-919. 通讯作者

13. Knockout of leucine aminopeptidase in Toxoplasma gondii using CRISPR/Cas9. Zheng, J., Jia, H.*, & Zheng, Y. International Journal for Parasitology, 2015, 45:141-148. 通讯作者

14. Characterization of aspartyl aminopeptidase from Toxoplasma gondii. Zheng, J., Cheng, Z., Jia, H.* & Zheng, Y. Sci Rep, 2016, 6: 34448. 通讯作者

15. Toxoplasma gondii Clp family protein: TgClpB1 plays a crucial role in thermotolerance. Cao, S., Nali Du, Chen, H., Pang, Yu., Zhang, Z., Zheng, J. Jia, H.* Oncotarget. 2017, 8:86117-86129.

16. Wang, M., Cao, S., Du, N., Fu, J., Li, Z., Jia, H.＊, Mingxin Song*. The moving junction protein RON4, although not critical, facilitates host cell invasion and stabilizes MJ members. Parasitology. 2017, 144(11): 1490-1497. 共同通讯

17. Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii. Yang, M., Zheng, J., Jia, H.,*, Song, M.* Parasitology. 2016, 143(11):1443-9. 共同通讯

18. Meng, X., ,  Zheng, J.,  He, X., Jia, H. *, Zhang, Y.* First characterization in China of Encephalitozoon cuniculi in the blue fox (Alopex lagopus). J Eukaryot Microbiol. 2014, 61(6):580-5.

19.  Meng, X., Zheng, J., Gao, Y., Zhang, Y*. & Jia, H* . Evaluation of spore wall protein 1 as an alternative antigen for the diagnosis of Encephalitozoon cuniculi infection of farmed foxes using an enzyme-linked immunosorbent assay. Veterinary Parasitology, 2014, 203: 331-334. 通讯作者

20. Jia, H., Nishikawa, Y., Luo, Y., Yamagishi, J., Sugimoto, C., Xuan, X., Characterization of a leucine aminopeptidase from Toxoplasma gondii. Mol Biochem Parasitol 170, 1-6.

21. Jia, H., Zhou, J., Ikadai, H., Matsuu, A., Suzuki, H., Igarashi, I., Fujisaki, K., Xuan, X., 2006. Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its use in serodiagnosis. Am J Trop Med Hyg 75, 843-850.

22. Jia, H., Liao, M., Lee, E., Nishikawa, Y., Inokuma, H., Ikadai, H., Matsuu, A., Igarashi, I., Xuan, X., 2007. Development of an immunochromatographic test with recombinant BgSA1 for the diagnosis of Babesia gibsoni infection in dogs. Parasitol Res 100, 1381-1384.

23. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Zhou, J., Lee, E.G., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2008. Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen. Exp Parasitol 118, 146-149.

24. Jia, H., Aboge, G.O., Terkawi, M.A., Goo, Y.K., Nishikawa, Y., Kuriki, K., Lee, K.K., Jang, H.K., Kim, S., Fujisaki, K., Xuan, X., 2009. Genetic diversity of two selected antigen loci in Babesia gibsoni Asian genotype obtained from Japan and Jeju island of South Korea. Vet Parasitol 162, 142-146.

25. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Luo, Y., Li, Y., Yamagishi, J., Nishikawa, Y., Igarashi, I., Sugimoto, C., Fujisaki, K., Xuan, X., 2009. Characterization of a leucine aminopeptidase of Babesia gibsoni. Parasitology 136, 945-952.

26. Jia, H., Terkawi, M.A., Aboge, G.O., Goo, Y.K., Ma, L., Zhou, J., Nishikawa, Y., Igarashi, I., Fujisaki, K., Xuan, X., 2009. Identification of secreted antigen 3 from Babesia gibsoni. Clin Vaccine Immunol 16, 944-948.