1、个人简历

   1.  亚洲1 型FMD病毒样颗粒展示O型FMDV优势中和表位的研究（项目编号：31101801）  国家自然科学基金  21万元  2012-2014  主持

   1. Mingxia Wang, Zhiqiang Xu, Wenming Liu, Minjie Li, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu.Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals。Res Vet Sci, 124:178–185.

   2. Wenming Liu, Baolin Yang, Mingxia Wang, Weifeng Liang, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu * (2017) Identification of a conserved conformational epitope in the VP2 protein of foot-and-mouth disease virus. Arch Virol, 162:1877–1885.

   3. Wenming Liu†, Baolin Yang†, Mingxia Wang, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu (2017) Identification of a conformational neutralizing epitope on the VP1 G-H loop of type A foot-and-mouth disease virus. (2017) Res Vet Sci, 115, 374–381.

   4. Baolin Yang, Mingxia Wang, Wenming Liu, Zhiqiang Xu, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu.  Identification of a serotype-independent linear epitope of foot-and-mouth disease virus. (2017).Arch Virol.2017 162, 3875–3880.

   5. Weifeng Liang, Guohui Zhou, Wenming Liu1,Baolin Yang, Chaosi Li, Haiwei Wang, Decheng Yang, Wenge Ma, Li Yu 1  Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody . Arch Virol (2016) 161:2705–2716

   6. Chaosi Li, Weifeng Liang, Wenming Liu, Decheng Yang, Haiwei Wang, Wenge Ma, Guohui Zhou*, Li Yu. Identification of a conserved linear epitope using a monoclonal antibody against non-structural protein 3B of foot-and-mouth disease virus Arch Virol (2016) 161:365–375

   7. Zhou G, Wang H, Wang F, Yu L. Recombinant Adenovirus Expressing Type Asia1 Foot-and-mouth Disease Virus Capsid Proteins Induces Protective Immunity against Homologous Virus Challenge in Mice. Res Vet Sci. 2013 Jun;94(3):796-802.

   8. Chai Z, Wang H, Zhou G, Yang D, Wang J, Yu L. Adenovirus-vectored type Asia1 foot-and-mouth disease virus (FMDV) capsid proteins as a vehicle to display a conserved, neutralising epitope of type O FMDV. Journal of Virological Methods. 2013,188(1-2):175-82.

   9. Xue M, Wang H, Li W, Zhou G, Tu Y, Yu L.Effects of amino acid substitutions in the VP2 B-C loop on antigenicity and pathogenicity of serotype Asia1 foot-and-mouth disease virus. Virol J. 2012,10;9(1):191.

   10. Haiwei Wang, Mei Xue, Decheng Yang, Guohui Zhou, Donglai Wu and Li Yu .Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype. J Gen Virol. 2012,93:1442-8.

   11. Yang D, Zhang C, Zhao L, Zhou G, Wang H, Yu Li.Identification of a conserved linear epitope on the VP1 protein of serotype O Foot-and-Mouth Disease Virus by neutralising monoclonal antibody 8E8. Virus Research. 2011，155（1），291-299.

   12. Haiwei Wang, Lei Zhao,Wan Li,Guohui Zhou,,Li Yu.Identification of a Conformational Epitope on the VP1 G-H Loop of Type Asia1 Foot-and-Mouth Disease Virus Defined by a Protective Monoclonal Antibody. Vet Microbiol. 2011, 148（2-4）:189-199

   1.周国辉. 表达亚洲1型口蹄疫病毒VLP的重组腺病毒及其应用，2010，中国，国家发明专利授权号：ZL201010114532.X

   2.周国辉. 抗口蹄疫病毒的单克隆抗体及其识别的表位和应用，2010，中国，国家发明专利授权号：ZL200810171257.8

   3.周国辉. O型口蹄疫病毒变异株及其编码基因和应用，2010，中国，国家发明专利授权号：ZL201010160669.9

   4.周国辉. 表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其应用，2014，中国，国家发明专利号ZL 201210030115.6

   5.周国辉. 表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其应用，2017，中国，国家发明专利号ZL 201410030113.2

   6.周国辉. A型口蹄疫病毒单克隆抗体识别的中和表位及其应用，2019，中国，国家发明专利号ZL 2016101183394.8

   7.周国辉.抗A型口蹄疫病毒中和性单克隆抗体及其应用，2019，中国，国家发明专利号ZL 201610183404.8

   8.周国辉. 分泌口蹄疫病毒共享型单克隆抗体10B10的杂交瘤细胞系及其应用，2019，中国，国家发明专利号ZL 201710349810.1

8、转基因安全证书

    表达O型口蹄疫病毒外壳蛋白的重组腺病毒rAdV-O-P12A3C疫苗生产应用的安全证书。 农基安证字（2018）第047号