1、个人简介

刘宏扬，博士，中国农业科学院哈尔滨兽医研究所助理研究员。主要从事以基因敲除小鼠为模型研究宿主天然免疫反应的机制研究。在Cell Reports（2篇）、Journal of Virology（2篇）、Journal of Immunology（1篇）等杂志发表第一作者科技论文5篇。

2、联系方式

电话：1336136126

邮箱：liuhongyang@caas.cn

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育背景

2019.09-2022.06 中国农业科学院哈尔滨兽医研究所 预防兽医学  博士

2016.09-2019.06 长江大学动物科学技术学院 养殖业 硕士

2012.09-2016.06 山东农业大学动物医学院 动物医学 本科

4、工作经历

2022.10至今 中国农业科学院哈尔滨兽医研究所 基础免疫创新团队 助理研究员

5、承担主要科研项目

1. 国家自然科学基金优秀青年基金项目：兽医免疫学（32322081，2024.01-2026.12） 200万元，参与；

2. 国家自然科学基金专项项目：非洲猪瘟病毒感染与致病机制（31941002，2019.07-2022.06）300万元，参与。

6、代表性文章

1. Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang*, Changjiang Weng*, African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway. Journal of Virology. 2024 Feb 14:e0183423.

2. Guangqiang Ye¹, Hongyang Liu¹, Xiaohong Liu, Weiye Chen, Jiangnan Li, Dongming Zhao, Gang Wang, Chunying Feng, Zhaoxia Zhang, Qiongqiong Zhou, Jun Zheng, Zhigao Bu, Changjiang Weng, Li Huang, African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING. Journal of Virology. 2023; 97(9): e0057723.

3. Li Huang^a, Weiye Chen^a, Hongyang Liu^a, Mengdi Xue^a, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun H, Yuntao Guan, Zhigao Bu*, Changjiang Weng*, African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase STING and IFN Signaling Pathways. Journal of Immunology. 2023, 210 (9): 1338-1350.

4. Qiongqiong Zhoua, Longfeng Zhanga, Qihong Lin, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Shuang Jiao, Jiangnan Li, Yandong Tang, Deshi Shi, Li huang*, Changjiang Weng*, Mechanism of PRV infection activating TLRs-NF-kB axis and AIM2 inflammasome to enhance inflammatory response. Journal of Virology. 2023, 97 (3).

5. Li Huang¹, Hongyang Liu¹, Guangqiang Ye¹, Xiaohong Liu, Weiye Chen, Zilong Wang, Shijun Zhou, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng*, ASFV pH240R affects the virulence of African swine fever virus by inhibiting type I interferon signaling and NLRP3-mediated inflammatory responses. Journal of Virology. 2023, 97 (2).

6. Hongyang Liu¹, Guangqiang Ye¹, Xiaohong Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Kunli Zhang, Li Huang*, Changjiang Weng*. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis. Cell Reports. 2022, 41, 111469.

7. Xiaohong Liu, Hongyang Liu, Guangqiang Ye, Mengdi Xue, Huibin Yu, Chunying Feng, Qiongqiong Zhou, Xuemin Liu, Longfeng Zhang, Shuang Jiao, Changjiang Weng*, Li Huang*. African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3. Veterinary Microbiology. 274 (2022) 109556.

8. Qiongqiong Zhou, Longfeng Zhang, Hongyang Liu, Guangqian Ye, Li Huang*, Changjiang Weng*. Isolation and Characterization of Two Pseudorabies Virus and Evaluation of Their Effects on Host Natural Immune Responses and Pathogenicity. Viruses, 2022 14 (4): 712.

9. Li Huang¹, Wenjie Xu¹, Hongyang Liu, Mengdi Xue, Xiaohong Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Xuemin Liu, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu, Tao Xiong*, and Changjiang Weng*, African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 toInhibit K63-Linked Ubiquitination of TBK1. Journal of Immunology, 2021 207(11): 2754-2769.

10. Li Huang#, Hongyang Liu#, Kunli Zhang, Qingwen Meng, Liang Hu, Yuanfeng Zhang, Zhida Xiang, Jiangnan Li, Yuying Yang, Yali Chen, Shangjin Cui, Hong Tang, Huadong Pei, Zhigao Bu, and Changjiang Weng, Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Reports. 2020, 32, 108044.

11. Kunli Zhang, Yuanfeng Zhang, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang*, Changjiang Weng*. DDX19 inhibits type I interferon production by disrupting TBK1-IKKε-IRF3 interactions and promoting TBK1 and IKKε degradation. Cell Reports. 2019 26: 1258-1272.