1、个人简历
李江南,博士,副研究员,硕士生导师,中国农业科学院哈尔滨兽医研究所基础免疫创新团队骨干成员。主要从事非洲猪瘟病毒和猪繁殖与呼吸综合征病毒调控宿主炎症反应研究。近年来,先后主持国家自然科学基金面上项目和“十三五” 国家重点研发计划项目子课题等项目。在PLoS Pathog和J Virol等专业杂志发表科技论文15余篇,获得中华农业科技奖1项。
2、联系方式
电话:0451-51051755
邮箱:lijiangnan521@163.com
通讯地址:黑龙江省哈尔滨市香坊区哈平路678号
3、教育经历
2008.09-2011.06 吉林大学预防兽医学专业 博士
2005.09-2008.06 吉林大学预防兽医学专业 硕士
2001.09-2005.06 西南大学(原西南农业大学)动物医学专业 学士
4、工作经历
2017.01-今 中国农科院哈尔滨兽医研究所 副研究员
2011.07-2016.12 中国农科院哈尔滨兽医研究所 助理研究员
5、承担项目
1. 中国农业科学院科技创新工程科学中心重点任务子课题:非洲猪瘟病毒对猪损伤与致死机制解析(250万),课题号:CAAS-CSLPDCP-2023002,2023.1-2027.12,主持,在研。
2. 国家自然科学基金面上项目:猪繁殖与呼吸综合征病毒非结构蛋白11抑制NLRP3炎症小体激活的分子机制(61万),课题号31302163,2019.01-2022.12,主持,结题。
3. 国家自然科学基金委非洲猪瘟基础研究重点专项:非洲猪瘟感染及致病机制研究(300万),课题号31941002,2019.7-2022.12,参与,结题。
4. “十三五” 国家重点研发计划项目子课题:以SPF猪为基础的高致病性猪繁殖与呼吸综合征病毒单因子发病模型的建立及其评价(30万),课题号2017YFD0501604-3,2016.07-2020.12,主持,结题。
5. 国家自然科学基金青年基金,PRRSV NSP1β与HSP40 互作抑制I型干扰素的产生分子机制(25万),课题号31302163,2014.1-2016.12,主持,结题。
6、代表性论文
1. Jiangnan Li 1, Jie Song 1, Shijun Zhou, Shuai Li, jia Liu, Ting Li, Zhaoxia Zhang, Xianfeng Zhang, Xijun He, Weiye Chen, Jun Zheng, Dongming Zhao, Zhigao Bu*, Li Huang *, Changjiang Weng *, Development of a New Effective African Swine Fever Virus Vaccine Candidate by Deletion of the H240R and MGF505-7R Genes Results in Sterile Immunity against the Eurasia Strain. J Virol. 2023, 97(10):e0070423.
2. Li Huang 1, Hongyang Liu 1, Guangqiang Ye 1, Xiaohong Liu, Weiye Chen, Zilong Wang, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Liang Hu, Huibin Yu, Shijun Zhou, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng *, Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses. J Virol.2023, 97(2):e0122722.
3. Jiangnan Li 1, Jie Song 1, Li Kang, Li Huang, Shijun Zhou, Liang Hu, Jun Zheng, Changyao Li , Xianfeng Zhang, Xijun He, Dongming Zhao, Zhigao Bu*, Changjiang Weng*. pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production. PLoS Pathog.2021, 17(7):e1009733.
4. Jie Song, Li Kang, Ting Li, Gaihong Zhao, Shijun Zhou, Li Huang, Jiangnan Li*, Changjiang Weng. Screening of PRRSV- and ASFV-encoded proteins involved in the inflammatory response using a porcine iGLuc reporter. J Virol Methods. 2020, 285:113958.
5. Jiangnan Li 1, Shengnan Wang 1, Changyao Li, Yonggang Liu, Gang Wang, Xijun He, Liang Hu, Yuanyuan Liu, Mengmeng Cui, Caihong Bi, Zengyu Shao, Xiaojie Wang, Tao Xiong, Xuehui Cai, Li Huang, Changjiang Weng*. Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. Vet Microbiol. 2017, 204: 35-42.
6. Li Huang, Tao Xiong, Huibin Yu, Quan Zhang, Kunli Zhang, Changyao Li, Liang Hu, Yuanfeng Zhang, Lijie Zhang, Qinfang Liu, Shengnan Wang, Xijun He, Zhigao Bu, Xuehui Cai, Shangjin Cui, Jiangnan Li* and Changjiang Weng*. Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex. Biochem J. 2017, 474: 2051-2065.
7. Li Jiangnan 1, Hu Liang 1, Liu Yuanyuan 1, Huang Li, Mu Yang, Cai Xuehui, Weng Changjiang*. DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation. J Immunol. 2015, 195(12): 5732-5749.