1、个人简介

黄丽，研究员，博士生导师，国家自然科学基金优秀青年基金获得者，中国农业科学院杰出青年英才。任农业农村部经济动物疫病重点实验室学术委员、中国生物化学与分子生物学会农业生物化学与分子生物学分会委员兼副秘书长、中国免疫学会兽医免疫学分会理事、中国畜牧兽医学会兽医传染病学分会青年委员、中国免疫学会黑龙江省免疫学分会理事、黑龙江省蛋白质组学学会理事、黑龙江省青年科技工作者协会会员、黑龙江省兽医免疫学重点实验室学术带头人、Frontiers in Immunology、Microorganisms、Animals等期刊客座主编、mLife期刊和中国农业科学杂志青年编委、Animal Diseases杂志科学编辑、Cell、Journal of Virology等杂志审稿人；2023年获得“哈尔滨市三八红旗手”荣誉称号；2024年当选黑龙江省妇女第十三次代表大会代表；主要从事非洲猪瘟病毒、猪伪狂犬病病毒等重要动物病毒逃逸宿主天然免疫机制研究；主持国家自然科学基金优青项目等国家级项目5项；在Cell Reports（3篇）、Autophagy、PLoS Pathogens (2篇)、Journal of Virology（5篇）、Journal of Immunology（2篇）等杂志发表第一作者或者通讯作者（含共同）科技论文20余篇；研发非洲猪瘟病毒ELISA抗体检测试剂盒2个，成果转化400万元；获得国家发明专利3项、中华农业科技奖1项、中国农业科学院科技成果奖1项。

2、联系方式

电话：0451-51051759

邮箱：highlight0315@163.com

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育背景

2007/09-2012/06 南京农业大学动物医学院 预防兽医学  博士

2005/09-2007/09 山东农业大学动物医学院  预防兽医学 本科

4、工作经历  

2012.07-2016.12 中国农业科学院哈尔滨兽医研究所 助理研究员

2017.01-2021.12 中国农业科学院哈尔滨兽医研究所 基础免疫创新团队 副研究员

2022.01至今，中国农业科学院哈尔滨兽医研究所，基础免疫创新团队 研究员

5、承担主要科研项目

1.国家自然科学基金优秀青年基金项目：兽医免疫学，（32322081，2024.01-2026.12） 200万元，主持；

2.中国农业科学院科学中心项目：禽流感和非洲猪瘟等畜禽重要疫病病原与宿主互作机制研究，（CAAS-CSLPDCP-202401，2024.01-2028.01），100万元，主持；

3.国家自然科学基金面上项目：波形蛋白识别非洲猪瘟病毒DNA激活NLRP3炎症小体的分子机制，（32270156，2023.01-2026.12）54万元，主持；

4.国家重点研发计划“非洲猪瘟亚单位疫苗创制”重点专项子课题：ASF亚单位疫苗的TCR和BCR免疫组库模型建立与验证（2021YFD1801300，2021.12-2024.11），100万元，主持；

5.黑龙江省自然科学基金优秀青年项目：非洲猪瘟病毒pI215L蛋白抑制I型干扰素产生的分子机制，（YQ2020C022，2020.07-2023.07），10万元，主持；

6.国家重点研发计划子课题：生物安全关键技术研发重点专项2018年度项目，（2018YFC1200902, 2018.06-2021.06），50万元，主持；

7.国家自然科学基金专项项目：非洲猪瘟病毒感染与致病机制，（31941002，2019.07-2022.06），300万元，参与；

8.国家自然科学基金青年基金：20S蛋白酶体亚基在脑心肌炎病毒复制与组装中的作用，（31300139，2014.01-2016.12），23万元，主持。

6、代表性文章

1. Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Hongyang Liu, Guangqiang Ye, Zhaoxia Zhang, Boli Hu, Li Huang*, Changjiang Weng*, Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication. Autophagy. 2025; 2511584.

2. Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang*, Changjiang Weng*, Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity. PLoS Pathogens. 2024; 20(4):e1012146. 

3. Xiaohong Liu, Hefeng Chen, Guangqiang Ye, Hongyang Liu, Chunying Feng, Weiye Chen, Liang Hu, Qiongqiong Zhou, Zhaoxia Zhang, Jiangnan Li, Xianfeng Zhang, Xijun He, Yuntao Guan, Zhengshuang Wu, Dongming Zhao, Zhigao Bu*, Changjiang Weng*, Li Huang*, African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways. PLoS Pathogens. 2024; 20(4):e1012136.

4. Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang*, Changjiang Weng*, African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway. Journal of Virology. 2024; 98(3):e0183423.

5. Jiangnan Li , Jie Song, Shijun Zhou, Shuai Li, Jia Liu , Tingting Li, Zhaoxia Zhang, Xianfeng Zhang, Xijun He, Weiye Chen, Jun Zheng, Dongming Zhao, Zhigao Bu, Li Huang*, Changjiang Weng*,  Development of a new effective African swine fever virus vaccine candidate by deletion of the H240R and MGF505-7R genes results in protective immunity against the Eurasia strain. Journal of Virology. 2023 97(10):e0070423.  

6. Guangqiang Ye, Hongyang Liu, Xiaohong Liu, Weiye Chen, Jiangnan Li, Dongming Zhao, Gang Wang, Chunying Feng, Zhaoxia Zhang, Qiongqiong Zhou, Jun Zheng, Zhigao Bu, Changjiang Weng, Li Huang, African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING. Journal of Virology. 2023; 97(9): e0057723.

7. Li Huang a, Weiye Chena, Hongyang Liua, Mengdi Xuea, Siqi Dong, Xiaohong Liu, Chunying Feng, Shinuo Cao, Guangqiang Ye, Qiongqiong Zhou, Zhaoxia Zhang, Jun Zheng, Jiangnan Li, Dongming Zhao, Zilong Wang, Encheng Sun, Hefeng Chen, Shuai Zhang, Xue Wang, Xianfeng Zhang, Xijun H, Yuntao Guan, Zhigao Bu*, Changjiang Weng*, African Swine Fever Virus HLJ/18 CD2v Suppresses Type I IFN Production and IFN-Stimulated Genes Expression through Negatively Regulating cGMP-AMP Synthase STING and IFN Signaling Pathways. Journal of Immunology. 2023, 210 (9): 1338-1350.

8. Qiongqiong Zhoua, Longfeng Zhanga, Qihong Lin, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Shuang Jiao, Jiangnan Li, Yandong Tang, Deshi Shi, Li Huang*, Changjiang Weng*, Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. Journal of Virology. 2023, 97 (3):e0000323.

9. Li Huang, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Weiye Chen, Zilong Wang, Shijun Zhou, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu*, Jiangnan Li*, Changjiang Weng*, Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses. Journal of Virology. 2023, 97 (2):e0122722.

10. Hongyang Liu1, Guangqiang Ye1, Xiaohong Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Kunli Zhang, Li Huang*, Changjiang Weng*. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis. Cell Reports. 2022, 41, 111469.

11. Xiaohong Liu, Hongyang Liu, Guangqiang Ye, Mengdi Xue, Huibin Yu, Chunying Feng, Qiongqiong Zhou, Xuemin Liu, Longfeng Zhang, Shuang Jiao, Changjiang Weng*, Li Huang*. African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3. Veterinary Microbiology. 274 (2022) 109556.

12. Qiongqiong Zhou, Longfeng Zhang, Hongyang Liu, Guangqian Ye, Li Huang*, Changjiang Weng*. Isolation and Characterization of Two Pseudorabies Virus and Evaluation of Their Effects on Host Natural Immune Responses and Pathogenicity. Viruses, 2022 14 (4): 712.

13. Li Huang, Jiangnan Li, Jun Zheng, Dan Li, Changjiang Weng, Multifunctional pMGF505-7R is a key virulence-related factor of African Swine Fever Virus. Frontiers in Microbiology, 2022. 852431.

14. Li Huang1, Wenjie Xu1, Hongyang Liu, Mengdi Xue, Xiaohong Liu, Kunli Zhang, Liang Hu, Jiangnan Li, Xuemin Liu, Zhida Xiang, Jun Zheng, Changyao Li, Weiye Chen, Zhigao Bu, Tao Xiong*, and Changjiang Weng*, African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1. Journal of Immunology, 2021 207(11): 2754-2769.

15. Li Huang#, Hongyang Liu#, Kunli Zhang, Qingwen Meng, Liang Hu, Yuanfeng Zhang, Zhida Xiang, Jiangnan Li, Yuying Yang, Yali Chen, Shangjin Cui, Hong Tang, Huadong Pei, Zhigao Bu, and Changjiang Weng, Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Reports. 2020, 32, 108044.

16. Kunli Zhang, Yuanfeng Zhang, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang*, Changjiang Weng*. DDX19 inhibits type I interferon production by disrupting TBK1-IKKε-IRF3 interactions and promoting TBK1 and IKKε degradation. Cell Reports. 2019 26: 1258-1272.

17. Li Huang, Tao Xiong, Huibin Yu, Quan Zhang, Kunli Zhang, Changyao Li, Liang Hu, Yuanfeng Zhang, Lijie Zhang, Qinfang Liu, Shengnan Wang, Xijun He, Zhigao Bu, Xuehui Cai, Shangjin Cui, Jiangnan Li and Changjiang Weng*. Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex. Biochemical Journal. 2017 474: 2051-2065.

18. Jiangnan Li, Shengnan Wang, Li Huang*, Changjiang Weng*. Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. Veterinary Microbiology. 2017, 204: 35-42.

19. Huibin Yu1, Li Huang1, Yuanfeng Zhang, Liang Hu, Shengnan Wang, Jiangnan Li, Xuehui Cai, Shangjin Cui, Changjiang Weng. An attenuated EMCV-HB10 strain acts as a live viral vector delivering a foreign gene. Journal of General Virology. 2016; 97(9):2280-90.

20. Li Huang, Qinfang Liu, Lijie Zhang, Quan Zhang, Liang Hu, Changyao Li, Shengnan Wang, Jiangnan Li, Yuanfeng Zhang, Huibin Yu, Yan Wang, Zhaohua Zhong, Tao Xiong, Xueshan Xia, Xiaojun Wang, Li Yu, Guohua Deng, Xuehui Cai, Shangjin Cui, Changjiang Weng*. Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK, Journal of Biological Chemistry, 2015, 290(46): 27618-32.

21. Li Huang, Ruibing Cao, Ning Wang, Ke Liu, Jianchao Wei, Hassan Isahga, Lijie Song Weiyong Zuo, Bin Zhou, Weiwu Wang, Xiang Mao*, Puyan Chen*. The design and Recombinant Protein expression of a Consensus Porcine Interferon: CoPoIFN-α, Cytokine, 2012, 57(1): 37-45.

22. Li Huang, Xiang Mao*, Najmoutin G. Abdulaev, Tony Ngo, Wei Liu, and Kevin D. Ridge. One-step Purification of a Functional, Constitutively Activated Form of Visual Arrestin, Protein expression and purification, 2012, 82(1): 55-60.

23. Ming-xia Sun, Li Huang, Rui Wang, Ya-ling Yu, Chen Li, Peng-peng Li, Xiao-chun Hu, Hong-ping Hao, Hassan. A. shag, Xiang Mao. Porcine Reproductive and Respiratory syndrome Virus Induce Autophagy to Promote Virus Replication. Autophagy. 2012, 8:1434-1447.

24. Li Huang, Yuanpeng Zhang, Yaling Yu, Mingxia Sun, Chen Li, Bo Ni, Xiuhua Wang, Puyan Chen, Xiang Mao*. Role of cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection on MARC-145 cells. Biochemical and Biophysical Research Communications. 2011, 414(3): 545-50.

7、专利

1. 黄丽，陈溥言，侯凤香，刘珂，曹瑞兵。一种复合猪α干扰素基因及其重组载体，ZL201010125057.6，发明专利，中国.

2. 步志高，翁长江，李江南，黄丽，陈伟业，赵东明，郑君，张朝霞，一种非洲猪瘟病毒基因缺失的重组减毒株及其制备方法与应用，ZL202211365536.4，发明专利，中国.

8. 产品转化

1. 非洲猪瘟病毒ELISA抗体检测试剂盒（p30），技术转让，广州悦洋生物技术有限公司

2. 非洲猪瘟病毒ELISA抗体检测试剂盒，技术转让，郑州中道生物技术有限公司