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首席科学家

1、个人简介

赵东明,博士,中共党员,中国农业科学院哈尔滨兽医研究所研究员,博士生导师,非洲猪瘟防控创新团队首席科学家,重要人兽共患病创新团队党支部书记,中组部国家级青年人才,中国农业科学院“农科英才”领军人才B类,黑龙江省“头雁行动计划”兽医病毒学创新研究团队骨干。自非洲猪瘟传入我国以来,一直致力于非洲猪瘟基础与防控研究,首次分离出我国非洲猪瘟强毒及基因II和I型低致死毒株,分别完成其基因组进化和致病性研究;解析了病毒颗粒精细结构并提出组装机制假说;作为核心骨干,创制出安全有效的非洲猪瘟弱毒疫苗,突破疫苗产业化瓶颈,完成农业转基因生物安全评价及临床试验;研制出非洲猪瘟抗体检测试剂盒,通过应急评价获生产许可,为我国非洲猪瘟防控提供理论及技术支撑。以第一或通讯作者(含共同)在Science、PLOS Pathogens、Protein and Cell、Journal of Virology、Journal of Biological Chemistry等期刊发表SCI论文22篇。主持国家十三五重点研发项目;部分成果被科技部入选“2019年度中国科学十大进展” ;获农业农村部授予的个人嘉奖、第十五届黑龙江省青年科技奖。

2、联系方式

(1)研究方向:兽医微生物及其分子生物学

(2)电话:0451-51051847

(3)邮箱:zhaodongming@caas.cn

(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

2001.09-2006.06 东北农业大学 动物医学专业 学士

2006.09-2012.06 中国农业科学院研究生院 预防兽医学专业 博士(硕博连读)

4、工作经历

2012.08-2013.12 日本学术振兴机构 博士后

2014.01-2016.06 东京大学医科学研究所 博士后

2016.6-至今  中国农业科学院哈尔滨兽医研究所 科研骨干一级/研究员

2018.7-今  中国农业科学院哈尔滨兽医研究所 “青年英才”院级入选者

2020.10-今 中国农业科学院哈尔滨兽医研究所 创新团队执行首席

2020.10-今 中国农业科学院哈尔滨兽医研究所 “农科英才”领军人才B类

2020.10-今 中国农业科学院哈尔滨兽医研究所 中组部国家级青年人才

5、承担项目

  1. 中组部国家级人才项目:2020.10-2023.10,170万元,项目负责人;

  2. 国家十三五重点研发计划:生物安全关键技术研发重点专项2018年度项目,总经费1415万元,2018.8-2021.6,项目负责人;

  3. 中国农业科学院“农科英才”领军人才B类配套项目:非洲猪瘟病原生态学、致病机制及防控技术研究(2020.10-2025.10),500万元;

  4. 兽医生物技术国家重点实验室自主课题:2018.01-2021.12,240万元,项目负责人;

  5. 国家自然基金委非洲猪瘟重大基础科学问题研究专项:非洲猪瘟病毒感染与致病机制(2019.07-2022.06)300万元,主要参与人;

  6. 黑龙江省“头雁行动计划”:兽医病毒学创新研究(2019.1-2023.12),团队骨干。

6、代表论文与著作

  1. Dongming Zhao*, Encheng Sun*, Lianyu Huang*, Leilei Ding*, Yuanmao Zhu*, Jiwen Zhang, Dongdong Shen, Xianfeng Zhang, Zhenjiang Zhang, Tao Ren, Wan Wang, Fang Li, Xijun He, Zhigao Bu# (2023). Highly lethal genotype I and II recombinant African swine fever viruses detected in pigs. Nat Commun. 2023 05 29;14 (1), 3096.

  2. Yuhang Zhang*, Zhenjiang Zhang, Fan Zhang, Jiwen Zhang, Jun Jiao, Min Hou, Nianchao Qian, Dongming Zhao#, Xiaofeng Zheng#, Xu Tan# (2023). ASFV transcription reporter screening system identifies ailanthone as a broad antiviral compound. Virol Sin.2023 Jun, 38 (3), 459-469.

  3. Yibrah Tekle Hagoss*, Dongdong Shen, Zhenjiang Zhang, Fang Li, Zhigao Bu#, Dongming Zhao# (2023). Novel Epitopes Mapping of African Swine Fever Virus CP312R Protein Using Monoclonal Antibodies. Viruses. 2023 02 17;15 (2)

  4. Rong-Hong Hua*, Jing Liu*, Shu-Jian Zhang, Ren-Qiang Liu, Xian-Feng Zhang, Xi-Jun He, Dong-Ming Zhao#, Zhi-Gao Bu# (2023). Mammalian Cell-Line-Expressed CD2v Protein of African Swine Fever Virus Provides Partial Protection against the HLJ/18 Strain in the Early Infection Stage. Viruses. 2023 06 28;15(7).

  5. Lulu Wang*, Dan Fu*, Weldu Tesfagaber, Fang Li, Weiye Chen, Yuanmao Zhu, Encheng Sun, Wan Wang, Xijun He, Yu Guo#, Zhigao Bu#, Dongming Zhao# (2022). Development of an ELISA Method to Differentiate Animals Infected with Wild-Type African Swine Fever Viruses and Attenuated HLJ/18-7GD Vaccine Candidate. Viruses.2022 Aug 6;14 (8)

  6. Encheng Sun*, Lianyu Huang*, Xianfeng Zhang*, Jiwen Zhang*, Dongdong Shen*, Zhenjiang Zhang, Zilong Wang, Hong Huo, Wenqing Wang, Haoyue Huangfu, Wan Wang, Fang Li, Renqiang Liu, Jianhong Sun, Zhijun Tian, Wei Xia, Yuntao Guan, Xijun He, Yuanmao Zhu, Dongming Zhao#, Zhigao Bu#.(2021)."Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection." Emerg Microbes Infect: 1-30.

  7. Encheng Sun*, Zhenjiang Zhang*, Zilong Wang*, Xijun He*, Xianfeng Zhang, Lulu Wang, Wenqing Wang, Lianyu Huang, Fei Xi, Haoyue Huangfu, Ghebremedhin Tsegay, Hong Huo, Jianhong Sun, Zhijun Tian, Wei Xia, Xuewu Yu, Fang Li, Renqiang Liu, Yuntao Guan, Dongming Zhao#, Zhigao Bu#. (2021). "Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020." Sci China Life Sci.

  8. Xiaohui Ju*, Fang Li*, Jingrui Li*, Chunyan Wu, Guangtao Xiang, Xiaomin Zhao, Yuchen Nan, Dongming Zhao#, Qiang Ding#. (2021). "Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction." Vet Microbiol 261: 109211.

  9. Jiahao Lia*, Yun Bai*, Fang Li, Yue Zhang, Qingyun Xie, Lei Zhang, Lizhong Hua, Qiyan Xiong, Yanke Shan, Zhigao Bu, Guoqing Shao, Zhixin Feng#, Dongming Zhao#, FeiLiu#. (2021). "Rapid and ultra-sensitive detection of African swine fever virus antibody on site using QDM based-ASFV immunosensor (QAIS)." Analytica Chimica Acta 1189 (2022) 339187.

  10. Wenzhuang Zhu, Kaiwen Meng, Yueping Zhang, Zhigao Bu, Dongming Zhao* and Geng Meng*. (2021). "Lateral Flow Assay for the Detection of African Swine Fever Virus Antibodies Using Gold Nanoparticle-Labeled Acid-Treated p72." Front Chem 9: 804981.

  11. Weldu Tesfagaber*, Lulu Wang*, Ghebremedhin Tsegay, Yibrah Tekle Hagoss, Zhenjiang Zhang, Jiwen Zhang, Haoyue Huangf, Fei Xi, Fang Li, Encheng Sun, Zhigao Bu#, and Dongming Zhao#. (2021). "Characterization of Anti-p54 Monoclonal Antibodies and Their Potential Use for African Swine Fever Virus Diagnosis." Pathogens 10(2).

  12. Yangming Song, Haixiang Huang, Yuzhen Hu, Jiwen Zhang, Fang Li, Xin Yin, Jianzhong Shi, Yanbing Li, Chengjun Li, Dongming Zhao*, Hualan Chen*. (2021). "A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis." PLoS Pathog 17(12): e1010141.

  13. Weiye Chen*, Dongming Zhao*, Xijun He*, Renqiang Liu*, Zilong Wang*, Xianfeng Zhang, Fang Li, Dan Shan, Hefeng Chen, Jiwen Zhang, Lulu Wang, Zhiyuan Wen, Xijun Wang, Yuntao Guan, Jinxiong Liu, Zhigao Bu (2020). "A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs." Sci China Life Sci 63(5): 623-634.

  14. Dan Fu*, Dongming Zhao*, Wei Zhang*, Guangshun Zhang, Mingyu Li, Zheng Zhang, Yuhui Wang, Dongdong Sun, Peng Jiao, Cheng Chen, Yu Guo, Zihe Rao (2020). Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding. Protein Cell 11(8): 606-612.

  15. Xing Liu*, Fang Li*, Jiwen Zhang, Lulu Wang, Jinliang Wang, Zhiyuan Wen, Zilong Wang, Lei Shuai, Xijun Wang, Jinying Ge, Dongming Zhao#, Zhigao Bu# (2020). The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein." J Biol Chem.

  16. Nan Wang*, Dongming Zhao*, Jialing Wang*, Yangling Zhang*, Ming Wang, Yan Gao, Fang Li, Jingfei Wang, Zhigao Bu, Zihe Rao, Xiangxi Wang. (2019). Architecture of African swine fever virus and implications for viral assembly. Science 366(6465): 640-644.

  17. Dongming Zhao*, Renqiang Liu*, Xianfeng Zhang*, Fang Li*, Jingfei Wang, Jiwen Zhang, Xing Liu, Lulu Wang, Jiaoer Zhang, Xinzhou Wu, Yuntao Guan, Wenye Chen, Xijun Wang, Xijun He, Zhigao Bu. (2019). Replication and virulence in pigs of the first African swine fever virus isolated in China. Emerg Microbes Infect 8(1): 438-447.

  18. Chunyang Gu; Xianying Zeng; Yangming Song; Yanbing Li; Liling Liu; Yoshihiro Kawaoka; Dongming Zhao#; Hualan Chen# (2018). Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses. Science China Life Sciences, 62(1): 76~83.

  19. Dongming Zhao*, Libin Liang*, Shuai Wang, Nakao T, Yanbing Li, Liling Liu, Yuntao Guan, Fukuyama S, Zhigao Bu, Kawaoka Y, Hualan Chen. (2017). Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response. J Virol 91: e02215-02216.

  20. Dongming Zhao, Satoshi Fukuyama, Yuko Sakai-Tagawa, Emi Takashita, Jason E Shoemaker and Yoshihiro Kawaoka. (2016). "C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection." Antimicrob Agents Chemother 60(3): 1902-1906.

  21. Dongming Zhao, Satoshi Fukuyama, Shinya Yamada, Tiago J. S. Lopes, Tadashi Maemura, Hiroaki Katsura, Makoto Ozawa, Shinji Watanabe, Gabriele Neumann and Yoshihiro Kawaoka. (2015)."Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus." J Virol 89(22): 11337-11346.

  22. Satoshi Fukuyama*, Hiroaki Katsura*, Dongming Zhao*, Makoto Ozawa*, Tomomi Ando, Jason E. Shoemaker, Izumi Ishikawa, Shinya Yamada, Gabriele Neumann, Shinji Watanabe, Hiroaki Kitano, Yoshihiro Kawaoka. (2015). "Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies." Nat Commun 6: 6600.

  23. Dongming Zhao, Libin Liang, Yanbing Li, Liling Liu, Yuntao Guan, Yongping Jiang, and Hualan Chen. (2012). "Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses." Proteomics 12(12): 1970-1982.

  24. Dongming Zhao, Libin Liang, Yanbing Li, Liling Liu, Yongping Jiang, and Hualan Chen. "Phylogenetic and Pathogenic Analyses of Avian Influenza A H5N1 Viruses Isolated from Poultry in Vietnam." PLoS One 7(11): e50959.

7、获奖情况

  1. 第十五届黑龙江省青年科技奖,2022年;

  2. 农业农村部“关于粮食和生猪生产专项工作及时奖励”的个人嘉奖,2022

  3. “揭示非洲猪瘟病毒结构及其组装机制”荣获科技部评选的“2019年度中国科学十大进展”,2020

  4.  发表在Emerging Microbes and Infections的论文获得该杂志2019年度最佳论文奖, 排名第一。

8、授权发明专利

  1. “基因缺失的减毒非洲猪瘟病毒及其作为疫苗的应用”(ZL201910348878.7),排名第三。

  2. 一种检测非洲猪瘟病毒抗体的胶体金免疫层析试纸卡(20211129182.1),排名第三。


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