汤艳东，博士，副研究员，硕士研究生导师，黑龙江省优秀青年基金获得者。入选斯坦福大学 2025 年度《全球前 2% 顶尖科学家榜单》，先后荣获 2016 年度中国农业科学院优秀博士后、2019 年度中国农业科学院杰出科技创新奖。现任《PLOS Pathogens》学术编辑、《Journal of Integrative Agriculture》青年编委。累计发表 SCI 论文 150 余篇，总引用 4300 余次，H 指数 37；其中以第一作者或通讯作者（含共同）在《The Lancet Microbe》(2026)《Advanced Science》(2025/2026)《Trends in Microbiology》(2024)《Journal of Advanced Research》(2025)《Emerging Microbes & Infections》(2019/2020/2024)《PLOS Pathogens》(2025a/2025b/2024)《Journal of Virology》(2014/2021/2022/2025a/2025b/2025c)《Journal of Biological Chemistry》(2021/2022)《FASEB J》等权威期刊发表论文 40 余篇。课题组长期围绕猪繁殖与呼吸综合征病毒（PRRSV）、伪狂犬病病毒（PRV）开展致病机制与新型疫苗研究；同时研发动物病毒来源的新型溶瘤病毒与基因治疗技术，并致力于原创性基础生物技术的开发。

1、联系方式

邮箱：tangyandong@caas.cn

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号，150069

2、教育经历

2011.09-2014.06  南方医科大学，医学免疫学，博士

2008.09-2011.06  中国农业科学院，生物化学与分子生物学，硕士

2003.09-2007.06  黑龙江八一农垦大学，生物科学，学士

3、工作经历

2020.01-至今  中国农科院哈尔滨兽医研究所，副研究员

2014.07-至2019.12  中国农科院哈尔滨兽医研究所，助理研究员

4、学术任职 

1). PLOS Pathogens 杂志学术编辑（Academic Editor）

2). Journal of Integrative Agriculture 青年编委

3). Archive of Virology 编委

5、在研项目

1). 国家重点研发计划子课题，濒危和青藏高原动物重要病毒新型疫苗技术研发（2023YFD1801303，2023-2027），50 万元，主持

2). 国家自然科学基金联合基金项目，非洲猪瘟病毒诱导血管内皮细胞凝血功能紊乱的分子机制（U25A20711，2026-2029），258 万元，参与

6、代表论文与著作(第一及通讯作者，包含共同)

1). Sun Y, Liu J, Xu SJ, et al. A Humanized Anti-gD Broadly Neutralizing Antibody Confers Complete Post-Exposure Protection against Pseudorabies Virus. Advanced Science (Weinh) 2026: e75771.

2). Wang TY, Li C, Cai XH, Shan T, Tang YD. Spillover of pseudorabies virus variants to humans: an urgent call for pseudorabies eradication in domestic pigs. Lancet Microbe. 2026, 24:101351.

3). Guo YQ, Wang MH, Tang N, Zhao YB, Wo LJ, Liang DX, Huang R, Tang YD, Sun YJ, Yin X. Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. Journal of Advanced Research. 2026, 80:1179-1196.

4). Bai YZ, Wang S, Sun Y, Liu YG, Zhang HL, Wang Q, Huang R, Rao CH, Xu SJ, Tian ZJ, An TQ, Cai XH, Tang YD. The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2. Journal of Virology. 2025, 99:e0182124.

5). Bai YZ, Xu H, Liu YG, Sun Y, Xu SJ, Wang MX, Wang Q, Tian ZJ, Leng CL, Wang G, An TQ, Cai XH, Zhang HL, Tang YD. Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine. Journal of Virology. 2025, 99(9):e0063625.

6). Na L, Zheng Y, Yang JB, Bao HL, Tang YD. The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? PLoS Pathogens. 2025, 21:e1013285.

7). Sun Y, Xu SJ, Zhou Y, Zhang Y, Zhang H, Le T, Bai YZ, Rao CH, Huo S, Zhou T, An TQ, Yin X, Yu F, Cai XH, Tang YD. A glycoprotein D-targeted lipid nanoparticle-encapsulated mRNA vaccine elicits strong protective immunity against pseudorabies virus. Journal of Virology. 2025, 99(11):e0147225.

8). Wang TY, Sun Y, Tang YD. Re-emergence of chikungunya virus in China by 2025: What we know and what to do? PLoS Pathogens. 2025, 21:e1013556.

9). Tang YD, Li Y, Cai XH, Yin X. Viral Live-Attenuated Vaccines (LAVs): Past and Future Directions. Advanced Science (Weinh). 2025, 12:e2407241.

10). Tang YD, Yu C, Cai XH. Novel technologies are turning a dream into reality: conditionally replicating viruses as vaccines. Trends in Microbiology. 2024, 32:292-301.

11). Wang TY, Meng FD, Sang GJ, Zhang HL, Tian ZJ, Zheng H, Cai XH, Tang YD. A novel viral vaccine platform based on engineered transfer RNA. Emerging Microbes and Infection. 2023, 12:2157339.

12). Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S, Yin X, Cai XH, Tang YD. SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. Journal of Biological Chemistry. 2022, 298:102511.

13). Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD. Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner. Journal of Virology. 2022, 96:e0131822.

14). Yang YL, Liu J, Wang TY, Chen M, Wang G, Yang YB, Geng X, Sun MX, Meng F, Tang YD, Feng L. Aminopeptidase N Is an Entry Co-factor Triggering Porcine Deltacoronavirus Entry via an Endocytotic Pathway. Journal of Virology. 2021, 95:e0094421.

15). Zhang HL, Li YM, Sun J, Zhang YY, Wang TY, Sun MX, Wang MH, Yang YL, Hu XL, Tang YD, Zhao J, Cai X. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. Journal of Biological Chemistry. 2021, 296:100435.

16). Yang YL, Meng F, Qin P, Herrler G, Huang YW, Tang YD. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerging Microbes and Infection. 2020, 9:457-468.

17). Wang TY, Fang QQ, Cong F, Liu YG, Wang HM, Zhang HL, Tian ZJ, Tang YD, Cai XH. The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis. Emerging Microbes and Infection. 2019, 8:1501-1510.

18). Tang YD, Guo JC, Wang TY, Zhao K, Liu JT, Gao JC, Tian ZJ, An TQ, Cai XH. CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing. FASEB J. 2018, 32:4293-4301.

19). Tang YD, Na L, Zhu CH, Shen N, Yang F, Fu XQ, Wang YH, Fu LH, Wang JY, Lin YZ, Wang XF, Wang X, Zhou JH, Li CY. Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum. Journal of Virology. 2014, 88:12296-310.

20). Yu C, Liu Q, Zhao Z, Zhai J, Xue M, Tang YD, Wang C, Zheng C. The emerging roles of MARCH8 in viral infections: A double-edged Sword. PLoS Pathogens. 2023, 19:e1011619.