1、个人简介

党光辉，男，博士，中国农业科学院哈尔滨兽医研究所动物细菌病创新团队副研究员。发表SCI文章20篇，其中以第一（含共第一）和通讯作者发表SCI文章10篇，获得授权发明专利2项。协助培养研究生9名。目前主要从事结核病和副结核病致病机制研究、亚单位疫苗和诊断制品的开发。

2、联系方式

（1）研究方向：兽医微生物及其分子生物学

（2）电话：0451-51051732

（3）邮箱：dangguanghui@caas.cn

（4）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号综合楼5008，150069。

3、教育经历

2004.09-2009.06 河南科技学院  动物医学  学士

2010.09-2012.06 福建农林大学  基础兽医学  硕士

2014.09-2018.01 中国农业科学院研究生院  预防兽医学  博士

4、工作经历

2013.07-2014.08 中国农业科学院哈尔滨兽医研究所  科研助理

2018.11-2023.07 中国农业科学院哈尔滨兽医研究所  博士后

2022.01-至今 中国农业科学院哈尔滨兽医研究所  副研究员

5、 承担的项目

青年科学基金项目, 32002256, Rv3194c蛋白酶在结核分枝杆菌逃逸IgG介导的免疫杀伤中的作用机制研究, 2021-01-01 至 2023-12-31, 24万元, 主持

6、代表论文与著作

1. Tang Yang#, Cui Y#, Jiang Yan, Shao M, Zang Xin, Dang G*, Liu S*. Characteristics of  Mycobacterium tuberculosis  serine protease Rv1043c in enzymology and pathogenicity in mice. J Integr Agric. 2023 June; Available online.

2. Shao M, Cui N, Tang Y, Chen F, Cui Y, Dang G*, Liu S*. A candidate subunit vaccine induces protective immunity against  Mycobacterium avium  subspecies  paratuberculosis  in mice. NPJ Vaccines. 2023 May 20;8(1):72.

3. Cui Y, Tang Y, Shao M, Zang X, Jiang Y, Cui Z, Dang G*, Liu S*. Mycobacterium tuberculosis protease Rv3090 is associated with late cell apoptosis and participates in organ injuries and mycobacterial dissemination in mice. Microb Pathog. 2022 Dec;173(Pt B):105880.

4. Zang X^#, Dang G^#, Cai Z, Shao M, Tang Y, Cao J, Cui Z, Liu S*. Extracellular DNase MAP3916c attacks the neutrophil extracellular traps and is needed for  Mycobacterium avium  subsp.  paratuberculosis  virulence. Vet Microbiol. 2022 Oct;273:109529.

5. Dang G, Cui Y, Wang L, Li T, Cui Z, Song N, Chen L, Pang H, Liu S*. Extracellular Sphingomyelinase Rv0888 of  Mycobacterium tuberculosis  Contributes to Pathological Lung Injury of  Mycobacterium smegmatis  in Mice  via  Inducing Formation of Neutrophil Extracellular Traps. Front Immunol. 2018 Apr 4;9:677.

6. Dang G, Cao J, Cui Y, Song N, Chen L, Pang H, Liu S*. Characterization of Rv0888, a Novel Extracellular Nuclease from  Mycobacterium tuberculosis . Sci Rep. 2016 Jan 8;6:19033.

7. Dang G, Chen L, Li Z, Deng X, Cui Y, Cao J, Yu S, Pang H, Liu S*. Expression, Purification and Characterisation of Secreted Esterase Rv2525c from  Mycobacterium tuberculosis . Appl Biochem Biotechnol. 2015 May;176(1):1-12.

8. Liu H^#, Dang G^#, Zang X, Cai Z, Cui Z, Song N, Liu S*. Characterization and pathogenicity of extracellular serine protease MAP3292c from  Mycobacterium avium  subsp.  paratuberculosis . Microb Pathog. 2020 Feb 11;142:104055.

9. Li H^#, Dang G^#, Liu H, Wang Z, Cui Z, Song N, Chen L, Liu S*. Characterization of a novel  Mycobacterium tuberculosis  serine protease (Rv3194c) activity and pathogenicity. Tuberculosis (Edinb). 2019 Dec;119:101880.

10. Chen L^#, Dang G^#, Deng X, Cao J, Yu S, Wu D, Pang H, Liu S*. Characterization of a novel exported esterase Rv3036c from  Mycobacterium tuberculosis . Protein Expr Purif. 2014 Dec;104:50-6.

11. Cui Y, Dang G, Wang H, Tang Y, Lv M, Zang X, Cai Z, Cui Z, Cao J, Liu S*, Song N*. DosR Regulates the Transcription of the Arginine Biosynthesis Gene Cluster by Binding to the Regulatory Sequences in  Mycobacterium bovis  Bacille Calmette-Guerin. DNA Cell Biol. 2022 Dec;41(12):1063-1074.

12. Zhao L, Wang Y, Wang JL, Zhao WH, Cheng HX, Ma YM, Chai HL, Zhang ZS, Wang LF, Miao ZQ, Ding YL, Sulijid J, Dang GH, Liu SY, Wang FL, Liu SG, Liu YH. Serological investigation and genotyping of  Mycobacterium avium  subsp.  paratuberculosis  in sheep and goats in Inner Mongolia, China. PLoS One. 2021 Sep 7;16(9):e0256628.

13. Cui Z, Dang G, Song N, Cui Y, Li Z, Zang X, Liu H, Wang Z, Liu S*. Rv3091, An Extracellular Patatin-Like Phospholipase in  Mycobacterium tuberculosis , Prolongs Intracellular Survival of Recombinant  Mycolicibacterium smegmatis  by Mediating Phagosomal Escape. Front Microbiol. 2020 Sep 11;11:2204.

14. Cao J, Dang G, Li H, Li T, Yue Z, Li N, Liu Y, Liu S*, Chen L*. Identification and Characterization of Lipase Activity and Immunogenicity of LipL from  Mycobacterium tuberculosis . PLoS One. 2015 Sep 23;10(9):e0138151.

15. Zhao L, Wang Y, Wang JL, Zhao WH, Cheng HX, Ma YM, Chai HL, Zhang ZS, Wang LF, Miao ZQ, Ding YL, Sulijid J, Dang GH, Liu SY, Wang FL, Liu SG, Liu YH. Serological investigation and genotyping of  Mycobacterium avium  subsp.  paratuberculosis  in sheep and goats in Inner Mongolia, China. PLoS One. 2021 Sep 7;16(9):e0256628.

16. Li Z, Liu H, Li H, Dang G, Cui Z, Song N, Wang Q, Liu S, Chen L. PE17 protein from  Mycobacterium tuberculosis  enhances  Mycobacterium smegmatis  survival in macrophages and pathogenicity in mice. Microb Pathog. 2019 Jan;126:63-73.

17. Chen P, Liu R, Huang M, Zhu J, Wei D, Castellino FJ, Dang G, Xie F, Li G, Cui Z, Liu S, Zhang Y. A unique combination of glycoside hydrolases in  Streptococcus suis  specifically and sequentially acts on host-derived αGal-epitope glycans. J Biol Chem. 2020 Jul 31;295(31):10638-10652.

18. Song N, Li Z, Cui Z, Chen L, Cui Y, Dang G, Li Z, Li H, Liu S. The prominent alteration in transcriptome and metabolome of  Mycobacterium bovis  BCG str. Tokyo 172 induced by vitamin B₁. BMC Microbiol. 2019 May 22;19(1):104.

19. Song N, Zhu Y, Cui Y, Lv M, Tang Y, Cui Z, Dang G, Zheng H, Liu S. Vitamin B and Vitamin C Affect DNA Methylation and Amino Acid Metabolism in  Mycobacterium bovis  BCG. Front Microbiol. 2020 Apr 22;11:812. doi: 10.3389/fmicb.2020.00812.

20. Cao J, Yi F, Tian Q, Dang G, Si W, Liu S, Yu S. Targeting the gram-negative bacteria peptidoglycan synthase MraY as a new approach for monoclonal antibody anti-bacterial activity. Hum Vaccin Immunother. 2017 Sep 2;13(9):2086-2091.

7、专利

1. 党光辉，刘思国，蔡珠明，崔子寅. 一种同时检测三种分枝杆菌的多重TaqMan荧光定量PCR试剂盒及其应用. 专利号：ZL202110731289.4

2. 刘思国，党光辉，陈利苹，李田田. 一种牛副结核间接ELISA检测试剂盒及其应用. 专利号：ZL202310215284.5